Salomó i Prat, Ernest (Date of defense: 2018-10-19)
Asymmetric hydrogenation of double bonds by means of organometallic catalysis is a powerful tool for organic synthesis; it is an efficient and simple method to produce valued chiral compounds. Among the ...
Aiguabella Font, Nuria (Date of defense: 2014-02-07)
The Pauson-Khand reaction (PKR) is, formally, a [2+2+1] cycloaddition involving an alkene, an alkyne and a carbon monoxide molecule, typically mediated or catalyzed by a cobalt (0) complex. The product ...
Cabré Montesinos, Albert (Date of defense: 2020-01-31)
The main contribution of this doctoral thesis has been devoted to the field of synthetic organic chemistry. The Pauson-Khand reaction (PKR) is a metal-catalyzed [2+2+1] cycloaddition between an alkyne, ...
Fuente Cebrián, Àlex de la (Date of defense: 2015-01-30)
Los iminoazúcares son productos estructuralmente análogos a los azúcares convencionales en los que un nitrógeno se sitúa sustituyendo al oxígeno endocíclico. Son sustratos capaces de mimetizar la ...
Donoghue, Craig (Date of defense: 2019-07-24)
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, ...
Rol Rúa, Álvaro (Date of defense: 2015-12-11)
Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a 14-amino-acid peptide discovered in 1973. It is a natural hormone whose biological activity is linked to five ...
Gallen Ortiz, Albert (Date of defense: 2019-02-01)
The Thesis deals with the preparation, coordination chemistry and use in asymmetric homogeneous catalysis of several optically pure P-stereogenic ligands containing a tert-butylmethylphosphino fragment. In ...
Cristóbal Lecina, Edgar (Date of defense: 2014-09-29)
La hidrogenación catalítica asimétrica es uno de los métodos más importantes en síntesis orgánica. Este proceso permite acceder a importantes productos quirales a escala multigramo utilizando hidrógeno ...
Frigolé Vivas, Marta (Date of defense: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to ...
Matarín Morales, Joan Antoni (Date of defense: 2021-12-15)
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles ...