Now showing items 10803-10822 of 11118

    Universal diagnostic platforms based on oligonucleotide codified nanoparticles and DNA microarray devices 

    Broto Avilés, Marta (Date of defense: 2017-09-18)

    La medicina personalitzada esta prenent rellevància últimament. Aquesta es basa en la monitorització simultània de diferents biomarcadors, els biomarcadors poden ser molècules de diferent naturalesa química. Aquest fet fa ...

    Universidade, externalidades e desenvolvimento regional: As dimensões socioeconômicas da expansão do ensino superior em Vitória da Conquista 

    Lopes, Roberto Paulo Machado (Date of defense: 2013-02-08)

    Este trabalho parte do entendimento de que a formação de economias de aglomeração está na base do desenvolvimento econômico de centros urbanos e regiões, especialmente das cidades médias, e defende a tese de que uma ...

    Universidade, sociedade e território no Brasil: Um estudo de caso na Bahia 

    da Silva Brito, Marialda (Date of defense: 2013-12-11)

    Esta pesquisa aborda a relação entre a universidade a sociedade e o território no Brasil e, particularmente no estado da Bahia. Especificamente são estudados alguns condicionantes sócio- territoriais de modo a verificar ...

    Universidades Interculturales en México. Reflexiones sobre Identidades a partir de un trabajo de campo en Espinal, Veracruz 

    Re, Arianna (Date of defense: 2013-10-17)

    En esta tesis se ha puesto en discusión las clasificaciones de identidad étnica e cultura dentro del marco de la educación intercultural, en lo específico se quiso problematizar la congruencia de las universidades ...

    Universitat, cultura i teatre a la dècada dels cinquanta: L'Agrupació de Teatre Experimental i el Teatre Viu 

    Ciurans Peralta, Enric (Date of defense: 2002-10-01)

    Amb aquesta recerca hem volgut recuperar la memòria de dues agrupacions escèniques sorgides a Barcelona a la dècada dels anys cinquanta, que per diversos motius simbolitzen des del nostre punt de vista l’inici del procés ...

    Universities free of Gender Violence. Communicative acts among the university community that overcome gender violence in Spanish universities 

    Schubert, Tinka Tabea (Date of defense: 2015-09-10)

    Violence against women at universities is a major problem that is widely analyzed and recognized in most countries, especially in the United States. Data evidences high incidence rates such as 19% of college students have ...

    Unraveling potential disease modifiers of myotonic dystrophy type 1 

    Koehorst, Emma Agathe (Date of defense: 2022-06-17)

    [spa] La distrofia miotónica tipo 1 (DM1) es un trastorno multisistémico, progresivo y no tratable con una expansión CTG en el gen DMPK que es la base de la patología. La compleja naturaleza multisistémica de la DM1 ...

    Unraveling the Fundamental Aspects of Enzyme-powered Micromotors 

    Arqué Roca, Francesc Xavier (Date of defense: 2023-01-24)

    [eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...

    Unravelling genetic predisposition to familial breast and ovarian cancer: new susceptibility genes and variant interpretation by in silico approaches 

    Moles Fernández, Alejandro (Date of defense: 2022-01-31)

    Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...

    Unravelling the molecular complexities of early-stage oestrogen receptor positive breast cancer to identify biomarkers of resistance to endocrine therapy 

    Bergamino Sirvén, Milana Arantza (Date of defense: 2022-11-29)

    [eng] 80% of breast cancer (BC) express positive estrogen receptors (ER+) and up to 15% of them also overexpress or amplify the human epidermal growth factor receptor 2 (HER2), which confers a molecular biology and different ...

    Unravelling the Role of Long Noncoding RNAs in the Context of Cell-growth and Regeneration 

    Amador Rios, Raziel (Date of defense: 2022-02-10)

    Long noncoding RNAs (lncRNAs) have proven biological roles in plethora cellular contexts. Nonetheless, only a handful have been clearly characterized, leaving thousands of newly discovered lncRNAs without an associated ...

    Unveiling novel components of the protein complex responsible for cGMP synthesis in retinal photoreceptors: role in cell physiology and disease 

    López Begines, Santiago (Date of defense: 2016-11-18)

    In photoreceptor cells of the retina, light triggers a protein G-mediated enzymatic cascade that leads to hydrolysis of cGMP. The drop in cGMP levels causes the closure of cGMP-channel at the plasma membrane, decreasing ...

    Unveiling novel functions of the trascriptional repressor HDAC7 in B lymphocyte development 

    Azagra Rodríguez, Alba (Date of defense: 2019-11-29)

    B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...

    Unveiling Protein-Substrate Interactions and Conformations that Influence Catalysis in Carbohydrate-Active Enzymes 

    Raich Armendáriz, Lluís Adrià (Date of defense: 2018-06-14)

    Enzymes have attracted the attention of chemists and biologists since long ago due to their molecular complexity and tremendous efficiency. They are highly specific catalysts that make chemical reactions possible at mild ...

    Unveiling the biological role of stigmasterol biosynthesis in tomato plants 

    Gutiérrez García, Laura (Date of defense: 2019-10-31)

    In plants, the sterol biosynthetic pathway leads to the production of a complex mixture of end-products, among which β-sitosterol, stigmasterol, campesterol, and cholesterol are the most abundant ones. Stigmasterol, the ...

    Unveiling the role of DXS-Interacting (DXI) proteins in the regulation of plastidial isoprenoid biosynthesis 

    Llamas Pámanes, Ernesto (Date of defense: 2017-09-15)

    Chloroplasts provide plants with metabolic pathways that are unique among eu- karoytes, including the methylerythritol 4-phosphate pathway (MEP) for the pro- duction of isoprenoids essential for photosynthesis and plant ...

    Unveiling the role of Slc7a7 in hematopoiesis 

    Giroud-Gernetant Deus, Judith (Date of defense: 2023-11-20)

    [eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...

    Unveiling the therapeutic potential of THC in endometrial cancer 

    Coll Iglesias, Laura (Date of defense: 2022-11-23)

    [eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...

    Unveiling viral structures by single-molecule localization microscopy 

    Arista Romero, Maria (Date of defense: 2021-06-28)

    Influenza A virus is one of the most outstanding human viruses. The major treatments against influenza are small analogues, monoclonal antibodies and vaccines, however, due to the fast mutation of the seasonal influenza ...

    Urban Trajectories. A comparative study between Rio de Janeiro’s Favelas and Johannesburg’s Townships 

    Rocha Franco, Sérgio H. (Date of defense: 2019-05-22)

    My general objective with this thesis is to contribute to the search for connections between postcolonial and critical understandings in urban studies. Building on my analysis of the urban trajectories of Rio de Janeiro’s ...