2024-03-28T18:25:19Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/814702017-08-30T03:37:30Zcom_10803_183col_10803_215
nam a 5i 4500
microbeam radiation therapy
minibeam radiation therapy
small-field dosimetry
Monte Carlo simulation
treatment planning system
dosimetry protocols
clinical trials
synchrotron radiation
Monte Carlo and experimental small-field dosimetry applied to spatially fractionated synchrotron radiotherapy techniques
[Barcelona] :
Universitat Politècnica de Catalunya,
2012
Accés lliure
http://hdl.handle.net/10803/81470
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Martínez Rovira, Immaculada,
autor
1 recurs en línia (173 pàgines)
Tesi
Doctorat
Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
2012
Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
Tesis i dissertacions electròniques
Sempau Roma, Josep,
supervisor acadèmic
Prezado Alonso, Yolanda,
supervisor acadèmic
TDX
Two innovative radiotherapy (RT) approaches are under development at the ID17 Biomedical
Beamline of the European Synchrotron Radiation Facility (ESRF): microbeam radiation
therapy (MRT) and minibeam radiation therapy (MBRT). The two main distinct characteristics
with respect to conventional RT are the use of submillimetric field sizes and spatial
fractionation of the dose. This PhD work deals with different features related to small-field
dosimetry involved in these techniques. Monte Carlo (MC) calculations and several experimental
methods are used with this aim in mind. The core of this PhD Thesis consisted of the
development and benchmarking of an MC-based computation engine for a treatment planning
system devoted to MRT within the framework of the preparation of forthcoming MRT
clinical trials. Additional achievements were the definition of safe MRT irradiation protocols,
the assessment of scatter factors in MRT, the further improvement of the MRT therapeutic
index by injecting a contrast agent into the tumour and the definition of a dosimetry protocol
for preclinical trials in MBRT.
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