2024-03-28T14:52:10Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/72382024-03-15T10:57:30Zcom_10803_236col_10803_690278
nam a 5i 4500
diferenciació cel.lular
activació cel.lular
molècules de la superfície cel.lular
granulòcits
cèl.lules Dendrítiques
macròfags
cell diferentiation
monòcits
cell activation
CD300
cell surface molecules
granulocytes
monocytes
macrophages
dendritic cells
Functional characterization of the CD300e leukocyte receptor
[Barcelona] :
Universitat Pompeu Fabra,
2011
Accés lliure
http://hdl.handle.net/10803/7238
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AAMMDDs2011 sp ||||fsm||||0|| 0 eng|c
978-84-694-3945-6
Brckalo, Tamara,
autor
Programa de doctorat en Biomedicina,
degree
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2011
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
López-Botet, M.
(Miguel)
supervisor acadèmic
TDX
The focus of this work was to functionally characterize the CD300e receptor expressed in human monocytes and myeloid dendritic cells and investigate the implications that receptor engagement has on their biology. We provide evidence formally supporting that CD300e functions as an activating receptor capable of regulating the innate immune response by triggering various pro- inflammatory functions including intracellular calcium mobilization, superoxide anion production, pro-inflammatory cytokine release and up-regulation of co-stimulatory molecules in myeloid cells. We also report that ligation of CD300e on the surface of monocytes results in their differentiation to functional MΦ2-like macrophages by an autocrine mechanism that involves M-CSF and its receptor (CD115).
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