2024-03-28T21:54:20Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/6687032021-01-13T13:25:58Zcom_10803_480col_10803_386518
nam a 5i 4500
Condicionamiento de lugar
Etanol
Cafeína
Extracellular signal-Regulated
Nucleus accumbens
Adicción
Behavioral and neurochemical assessment of the role of ERK pathway in the psychopharmacological effects of ethanol, caffeine and of their interaction
[Castelló] :
Universitat Jaume I,
2020
Accés lliure
http://hdl.handle.net/10803/668703
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Porru, Simona,
autor
Programa de Doctorat en Psicologia,
degree
1 recurs en línia (167 pàgines)
Tesi
Doctorat
Universitat Jaume I. Escola de Doctorat
2020
Universitat Jaume I. Escola de Doctorat
Tesis i dissertacions electròniques
Correa Sanz, Mercè,
supervisor acadèmic
Acquas, Elio,
supervisor acadèmic
TDX
The abundant expression of Extracellular signal-Regulated Kinase (ERK) in brain areas of addiction emphasizes the relevance of this kinase in modulating behavioral functions mediated by these circuits. Another biochemical factor involved in this process is Dopamine and cAMP-regulated phosphoprotein Mr 32,000 kDa (DARPP-32), which regulates the activity and the phosphorylation state of ERK pathway. Thus, the general aim of the present doctoral
thesis was to study the role of ERK in terms of protein kinase expression induced by
ethanol, caffeine and their association, and its relationship with some behavioral
responses in validated animal models of drug addiction such as the response to stimuli
associated to their intrinsic properties and conditioned to the environment (place
conditioning), or the psychomotor activation mediated by these substances.
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