2024-03-28T12:31:55Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/6654922024-03-15T10:57:22Zcom_10803_236col_10803_690278
nam a 5i 4500
Corte y empalme arternativo de RNA
Transcriptómica
Interacciones proteína-proteína
Regulación post-transcripcional
Bases de datos bioinformáticas
Alternative splicing
Transcriptomics
Protein-protein interactions
Post-transcriptional regulation
Biological databases
Functional impact of alternative splicing in vertebrate proteomes across tissues and cell types
[Barcelona] :
Universitat Pompeu Fabra,
2019
Accés lliure
http://hdl.handle.net/10803/665492
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Tapial Rodríguez, Javier,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (174 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2018
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Irimia, Manuel,
supervisor acadèmic
TDX
Alternative splicing (AS) is a post-transcriptional mechanism for gene expression regulation affecting almost every multiexonic gene in mammals. However, the impact of AS at the proteomic level remains under debate. In this thesis, we explored the landscape of AS across a variety of tissues, cell types and developmental stages in human, mouse and chicken, through the analysis of a panel of more than 300 publicly available RNA-seq samples. We confirm the presence of highly specific AS programmes in neural, muscle, testis and pluripotent cells in these species, and identify additional conserved modules of co-regulated AS events in kidney, liver, adipose tissue and immune cells by the application of a network analysis approach. In addition, we describe a subset of exons undergoing AS in virtually all analysed tissues and cell types. These exons are enriched in genes of pathways related to regulation of gene expression, where they likely operate through their translation into alternative protein isoforms coexisting at the single cell level.
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