2024-03-29T09:51:04Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/516602017-09-03T16:43:24Zcom_10803_1col_10803_31832
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Hepatologia
Hepatología
Hepathology
Trasplantament d'òrgans
Trasplante de órganos
Transplantation of organs
Characterization and prevention of the “small-for-size” syndrome in a porcine model of hepatic transplant
[Barcelona] :
Universitat de Barcelona,
2011
Accés lliure
http://hdl.handle.net/10803/51660
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Hessheimer, Amelia Judith,
autor
1 recurs en línia (120 pàgines)
Tesi
Doctorat
Universitat de Barcelona. Facultat de Medicina
2011
Universitat de Barcelona. Facultat de Medicina
Tesis i dissertacions electròniques
Fondevila Campo, Constantino,
supervisor acadèmic
García-Valdecasas Salgado, Juan Carlos,
supervisor acadèmic
TDX
The hypothesis of this doctoral thesis is two-fold:
1. Excessive portal vein flow is present immediately after portal reperfusion in the recipient and is the instigating factors in a series of events that ultimately lead to the development of “small-for-size” syndrome (SFSS).
2. A calibrated portocaval shunt prevents postreperfusion portal hyperperfusion and, thereby, the development of SFSS in partial liver grafts.
The objectives of this doctoral thesis are as follows:
1. To produce a porcine model of acute SFS injury that does not use venovenous bypass, in order to study the presentation of SFSS and characterize the cellular lesion in relation to altered hepatic hemodynamics.
2. To study the effects of modifying portal vein flow through the creation of portocaval shunts of different sizes, each calibrated to achieve a distinct decrease in the amount of flow ultimately reaching the SFS liver graft.
3. To determine the optimal decrease in the amount of portal vein flow that is capable of preventing the deleterious consequences of portal hyperperfusion and improving postoperative graft function and survival in SFS liver grafts.
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