2024-03-28T16:13:03Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/4038872024-03-15T10:57:22Zcom_10803_236col_10803_690278
nam a 5i 4500
Snail1
Cancer
Fibroblasts activation
Invasion
Tumorigenesis
Cáncer
Fibroblastos activos
Invasión
Tumorigénesis
Snail1 expression in mesenchimal cells promotes tumorigenesis and tumor progression
[Barcelona] :
Universitat Pompeu Fabra,
2017
Accés lliure
http://hdl.handle.net/10803/403887
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Alba Castellón, Lorena,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (137 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2016
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
García de Herreros, Antonio,
supervisor acadèmic
TDX
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that the function of Snail1 in fibroblasts and mesenchymal stem cells (MSCs) also contributes to tumor progression. In tumors with a mesenchymal origin, expression of Snail1 in oncogenic MSCs is needed to maintain their tumorigenic capacity and is required in vivo for tumor formation. Therefore, its deletion results in the absence of tumors. In tumors with an epithelial origin, we demonstrated that Snail1 expression in stromal fibroblasts is required to promote tumor cell invasion. Fibroblasts are activated in a Snail1-dependent manner by factors such as TGF- released by epithelial tumor cells. As response, fibroblasts secrete prostaglandin E2 which contributes to tumor invasion. Consequently, depletion of Snail1 in in vivo cancer models reduces the invasion to adjacent tissues and decreases metastasis. These results suggest a key role for Snail1 in tumor progression that is not limited to its expression in epithelial cells.
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