2024-03-29T15:44:24Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3951722024-03-15T10:58:01Zcom_10803_236col_10803_690279
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Investigación neurocientífica
Neuroscientic research
Cerebro
Brain
Spontaneous brain activity: how dynamics and topology shape the emergent correlation structure
[Barcelona] :
Universitat Pompeu Fabra,
2016
Accés lliure
http://hdl.handle.net/10803/395172
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Bettinardi, Ruggero G.,
autor
Programa de doctorat en Tecnologies de la Informació i les Comunicacions,
degree
1 recurs en línia (207 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
2016
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
Tesis i dissertacions electròniques
Deco, Gustavo,
supervisor acadèmic
TDX
Neuroscienti c research in the last decades has revealed that ongoing
brain activity exhibits highly structured spatio-temporal
patterns of neural activations. The fundamental core of this
endogenously generated correlation structure re
ects, to a large
extent, the complex anatomical organization of the central nervous
system, whereas the variability of spontaneous brain activity
is determined by regional properties. These cellular and circuit
properties are in turn modulated either by external stimuli and
ongoing computations as well as by signi cant changes in local dynamics
due to the internal system's physiology, such as sleep, or
induced by external factors, such as injuries, diseases, hypnosis or
psychoactive substances. In this dissertation we will demonstrate
how manipulations of regional dynamics and of the topological
structure de ned by anatomy determine changes in the emergent
large-scale correlation structure displayed by spontaneous brain
activity, and how this can be used to shed light on the intriguing
but still elusive relationship between structure and function.
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