2024-03-29T13:09:02Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3864412024-03-15T10:57:30Zcom_10803_236col_10803_690278
nam a 5i 4500
Morphogenesis
Head involution
Epidermis
Hedgehog
Actomyosin cable
Involució del cap
Cable d'actomyosina
Morfogènesi
Head involution in Drosophila melanogaster: on the role of supracellular actomyosin structures in tissue bending, spreading, and positioning
[Barcelona] :
Universitat Pompeu Fabra,
2016
Accés lliure
http://hdl.handle.net/10803/386441
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Czerniak, Natalia Dorotea,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (151 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2015
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Solon, Jérôme,
supervisor acadèmic
TDX
Morphogenesis creates a plethora of complex shapes in plants and animals. We devote this work to the study of Drosophila head involution (HI), a late embryogenetic process, which involves complete rearrangement of the head tissues, internalization of the brain and spreading of the epidermis. We show, for the first time, the complete kinetics of HI with high spatial and temporal resolution.
We describe the movements leading to the internalization of the embryonic brain, its “sculpting” by apoptosis, and cell removal by hemocytes. We then focus on the epidermal progression over the head, which can be divided into two phases: rolling and sliding. We show that both phases are powered by a supracelullar actomyosin cable. We also show that the spreading of the epidermis is spatially controlled resulting in segments of equal width being precisely positioned along the AP axis.
This positional control is performed by patterned tensile forces along the epidermal layer regulated by hedgehog signaling. Our study reveals a mechanism by which genes involved in body segmentation are also regulating morphogenesis.
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