2024-03-29T13:22:22Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/385232024-03-15T10:57:35Zcom_10803_236col_10803_690278
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Alternative splicing
Atlantic halibut
Pleuronectiformes
Puberty
Senegalese sole
Expressió gènica
Sistema kisspeptina
Llenguado senegalès
Peixos teleostis
Empalmament alternatiu
Neuroendocrine control of puberty in vertebrates : characteriization of the kisspeptin system in flatfish
[Barcelona] :
Universitat Pompeu Fabra,
2011
Accés lliure
http://hdl.handle.net/10803/38523
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AAMMDDs2011 sp ||||fsm||||0|| 0 eng|c
978-84-695-0048-4
Mechaly, Alejandro S.,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (166 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2011
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Piferrer Circuns, Francesc,
supervisor acadèmic
Viñas de Puig, Jordi,
supervisor acadèmic
TDX
The recently discovered decapeptide kisspeptin and its G-protein coupled receptor
form a signaling system expressed ubiquitously and are implicated in a variety of still
poorly characterized functions. In the brain, kisspeptin is secreted by specific
neurons and its receptor is localized in GnRH neurons. Kisspeptin signaling has
been fully established in the control of the onset of puberty in vertebrates, from fish to
mammals. In this study, we characterized the kisspeptin gene in the Senegalese sole
and characterized the kisspeptin receptor genes in both the Senegalese sole and in
the Atlantic halibut. In contrast to other fish species, the two species analyzed here
showed only the presence of one ligand and one receptor, probably as a
consequence of the genome reduction characteristic of Pleuronectiformes. However,
in both cases we found an alternative splicing mechanism based on intron retention
that produces also non-functional isoforms, but whether this is part of a mechanism
to control abundance of the active gene product is still not known. We document
spatial and temporal changes of expression of kisspeptin and its receptor in the
brain, pituitary and gonads related to the annual reproductive cycle. Finally, we
present the first evidence of a possible link between energy balance and
reproduction mediated by kisspeptin signaling in a non-mammalian vertebrate.
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