2024-03-28T10:28:34Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3830602024-03-15T10:57:24Zcom_10803_236col_10803_690278
nam a 5i 4500
Tandem repeats
Gene expression
Great apes
Evolution
Genetic diversity
Repeticiones en tandem
Expression génica
Grandes simios
Evolución
Diversidad genética
Tandem repeat variation in human and great ape populations and its impact on gene expression divergence
[Barcelona] :
Universitat Pompeu Fabra,
2016
Accés lliure
http://hdl.handle.net/10803/383060
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Carvalho, Tiago Loureiro de,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (77 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2016
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Marquès i Bonet, Tomàs,
supervisor acadèmic
TDX
Genetic variation in humans and the great apes has been amply explored using a wide variety of markers, among them tandem repeats (TRs). Because of the nature of TRs, highly variable in length due to its high mutation rate, they are an important source of genetic variation, and thus especially informative in fields such as population and conservation genetics. Particularly, they are still often used to illuminate natural populations complex evolutionary histories and structure.
TR variation is also associated with several pathological conditions, and hypothesized to have an important role in the evolution of gene regulation.
In this work a recently developed TR genotyping algorithm was applied on human and nonhuman great apes whole-genome sequencing data. The analysis of the TR variation indicate that this information is useful to describe fine scale population variation, and hints at a substantial contribution of TRs to gene expression divergence during great apes evolution.
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