2024-03-28T17:20:39Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3824842024-03-15T10:57:30Zcom_10803_236col_10803_690278
nam a 5i 4500
Maternal neglect
Communal nest
Neuroinflammation
Tryptophan-kynurenine metabolism
Cocaína
Sistema dopaminérgico
Negligència maternal
Niu comunal
Neuroinflamació
Cocaïna
Sistema dopaminèrgic
Transtorno por uso de sustancias
Neurobiological links between depression and drug dependence
[Barcelona] :
Universitat Pompeu Fabra,
2016
Accés lliure
http://hdl.handle.net/10803/382484
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Gracia Rubio, Irene,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (297 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2016
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Valverde Granados, Olga,
supervisor acadèmic
TDX
Early life experiences play a key role in brain function and behaviour. Maternal separation produced negative early life experiences that induce emotional alterations. Contrary, the communal nest has been proposed as a protective model that may reduce the vulnerability of individuals to suffer psychiatric disorders. Moreover, early-life stress enhances the vulnerability to develop substance use disorders, principally during adolescence. Hence, depressive states are associated with drug use disorders and abuse vulnerability since depressed patients could consume drugs to alleviate their symptoms. Our results lead us to propose that detrimental early life events such as maternal neglect reproduces most of the behavioural and neurochemical alterations associated with emotional disorders in mice. In addition, maternal separation could be useful to study the comorbidity between depression and substance use disorder since induces alterations in emotional and cocaine addictive behaviours as well as in the dopaminergic system. However, in our conditions, we cannot confirm the protective role of communal nest due to the behavioural alterations found in these mice, probably because this breeding condition involves energetic cost and increases the competition for food in pups.
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