2024-03-28T15:27:05Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3181672024-03-15T10:57:24Zcom_10803_236col_10803_690278
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Immunologia
Immunology
Cèl·lules B
B cells
Marginal Zone B Cells
Cell signaling
Immunoglobulines
Immunoglobulins
TACI
mTOR
TLR9
NF-kB
Role of mTOR in the activation of marginal zone B cells by TACI
[Barcelona] :
Universitat Pompeu Fabra,
2015
Accés lliure
http://hdl.handle.net/10803/318167
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Gentile, Maurizio,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (142 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2014
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Cerutti, Andrea,
supervisor acadèmic
TDX
The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that
mount rapid protective antibody responses to polysaccharides and lipids from bloodborne
viruses and bacteria. These antigens activate MZ B cells by engaging
somatically recombined B cell receptors (BCRs) and germline-encoded patternrecognition
receptors, including Toll-like receptors (TLRs). MZ B cells receive additional
co-stimulatory signals from a proliferation-inducing ligand (APRIL) and B cellstimulating
factor of the TNF family (BAFF), two tumor necrosis factor (TNF)-related
cytokines released mainly by macrophages, dendritic cells and neutrophils in response
to microbes. BAFF and APRIL stimulate MZ B cells through a poorly characterized
receptor called transmembrane activator and CAML interactor (TACI). Here we show
that TACI induces antibody production and class switching by activating the kinase
mammalian target of rapamycin (mTOR) through MyD88, an adaptor protein usually
associated with TLRs. The discovery of this rapamycin-sensitive signalling pathway
may facilitate the development of novel strategies for the modulation of protective or
pathogenic antibody responses emanating from MZ B cells.
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