2024-03-28T13:42:09Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/3109492024-03-15T10:58:02Zcom_10803_236col_10803_690279
nam a 5i 4500
Computational model
Lumped model
Patient-specific model
Intrauterine growth restriction
Fetal circulation
Cardiac remodelling
Doppler imaging
Aortic isthmus
Cerebral arteries
Umbilical artery
Placenta
Sarcomere
Second harmonic generation
Cardiac cell
Electromechanical model
Elastic modulus
Model computacional
Model computacional
Model agrupat
Model específic del pacient
Restricció de creixement intrauterine
Circulació fetal
Remodelació cardíaca
Doppler
Istme aòrtic
Artèries cerebrals
Artèria umbilical
Sarcòmer
Segona generació d'harmònics
Cèl•lula cardíaca
Model electromecànic
Calci
Mòdul d'elasticitat
Multiscale cardiovascular analysis and simulations for the understanding of intra-uterine cardiovascular remodelling
[Barcelona] :
Universitat Pompeu Fabra,
2015
Accés lliure
http://hdl.handle.net/10803/310949
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García Cañadilla, Patricia,
autor
Programa de doctorat en Tecnologies de la Informació i les Comunicacions,
degree
1 recurs en línia (148 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
2015
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
Tesis i dissertacions electròniques
Bijnens, Bart,
supervisor acadèmic
Crispi Brillas, Fàtima,,
supervisor acadèmic
Gratacós Solsona, Eduard,
supervisor acadèmic
TDX
Cardiovascular diseases are nowadays one of the major causes of death in developed countries. Besides the already known risk factors such as lifestyle and genetics, there is a growing evidence that adverse remodelling during prenatal life presents a risk factor for some cardiovascular diseases at later life. Recent studies have demonstrated that fetuses with intra-uterine growth restriction show cardiovascular remodelling at organ, vascular and also cellular and subcellular level, and moreover these changes persist postnatally. However this is a complex mechanism that needs to be further investigated. Currently, Doppler ultrasonography is one of the techniques most used to assess the fetal cardiovascular status and to study the heart and vascular remodelling in clinical practice. However, some of underlying hemodynamic and vascular changes cannot be assessed clinically and more sophisticated techniques are needed. Computational modelling of biological systems arises as a powerful tool to overcome this challenge, to support clinicians and to improve the understanding of different pathologies. In this thesis we proposed the use of computational models of fetal circulation, of cardiac cells and also image-processing tools, to improve the understanding of intra-uterine cardiac remodelling that takes place at different scales of the fetal cardiovascular system, and also to estimate the patient-specific hemodynamic properties that cannot be directly assessed from clinical measurements. The results arising from this thesis demonstrate that computational models are able to improve the understanding and detection of the intra-uterine cardiovascular remodelling by means of patient-specific simulations.
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