2024-03-28T14:04:51Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/2955832024-03-15T10:57:32Zcom_10803_236col_10803_690278
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Selenoprotein
Selenocysteine
Gene prediction
Genome annotation
Phylogeny
Selenophosphate synthetase
Genomics
Selenoproteína
Selenocisteína
Predicción de genes
Anotación de genomas
Filogenia
Selenofosfato sintetasa
Genòmica
Computational genomics of selenoproteins
[Barcelona] :
Universitat Pompeu Fabra,
2015
Accés lliure
http://hdl.handle.net/10803/295583
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Mariotti, Marco,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (248 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2013
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Guigó Serra, Roderic,
supervisor acadèmic
TDX
Selenoproteins are a diverse class of proteins containing selenocysteine, the 21st
aminoacid. Selenocysteine is inserted co-translationally, recoding very specific
UGA codons through a dedicated machinery. Standard gene prediction programs
consider UGA only as translational stop, and for this reason selenoprotein genes
are typically misannotated. In the past years, we developed computational tools
to predict selenoproteins at genomics scale. With these, we characterized the set
of selenoproteins across many sequenced genomes, and we inferred their phylogenetic
history. We dedicated particular attention to selenophosphate synthetase,
a selenoprotein family required for selenocysteine biosynthesis, that can be used
as marker of the selenocysteine coding trait. We show that selenoproteins went
through a very diverse evolution in different lineages. While very conserved in
vertebrates, selenoproteins were lost independently in many other organisms. Using
genome sequencing, we traced with precision the path of genomic events that
lead to recent selenoprotein extinctions in certain fruit flies.
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