2024-03-29T00:37:57Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/1286782024-03-15T10:57:17Zcom_10803_236col_10803_690278
nam a 5i 4500
Bioinformatics
Multiple sequence alignment
Alignment evaluation
Large-scale alignment
Protein structure
RNA structure
Bioinformática
Alineamiento múltiple de secuencias
Evaluación de alineamientos
Alineamientos múltiples de secuencia a gran escala
Estructura de proteínas
Estructura de ARN
Improving the accuracy and the efficiency of multiple sequence alignment methods
[Barcelona] :
Universitat Pompeu Fabra,
2014
Accés lliure
http://hdl.handle.net/10803/128678
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Kemena, Carsten,
autor
Programa de doctorat en Biomedicina,
degree
1 recurs en línia (112 pàgines)
Tesi
Doctorat
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
2012
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
Tesis i dissertacions electròniques
Notredame, Cedric,
supervisor acadèmic
TDX
Sequence alignment is one of the basic methods to compare biological sequences and the cornerstone of a wide range of different analyses. Due to this privileged position at the beginning of many studies its accuracy is of great importance, in fact, each result based on an alignment is depending on the alignment quality. This has been confirmed in several recent papers investigating the effect of alignment methods on phylogenetic reconstruction and the estimation of positive selection. In this thesis, I present several projects dedicated to the problem of developing more accurate multiple sequence alignments and how to evaluate them. I addressed the problem of structural protein alignment evaluation, the accurate structural alignment of RNA sequences and the alignment of large sequence data sets.
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