2024-03-28T13:34:33Zhttps://www.tdx.cat/oai/requestoai:www.tdx.cat:10803/227012024-03-15T10:57:20Zcom_10803_236col_10803_690278
00925njm 22002777a 4500
dc
Marfil Vives, Vanessa
author
2010-07-22
Hhex transcription factor is expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development. The pleiotropic effect of Hhex in the embryo and its dual role as a transcriptional repressor/activator suggest the presence of different interaction partners capable of modulating its activity and function. In the current study we identified two new Hhex protein interactors: SOX13 and c-Myc.
We show that Hhex interacts directly with SOX13. By doing so, Hhex sequesters SOX13 from the SOX13•TCF1 complex, overturning SOX13-dependent repression of the Wnt pathway. On the other hand, Hhex induces proliferation of non-tumorigenic human fibroblast through a Myc-dependent mechanism. Hhex and c-Myc interact directly upregulating Cyclin D1, a c-Myc target gene involved in cell cycle progression and proliferation. Elevation of Cyclin D1 might be the final effector of Hhex capacity to regulate cell proliferation.
978-84-694-4301-9
http://hdl.handle.net/10803/22701
B.21549-2011
Liver
Endoderm
SOX 13
Interactor
Proliferación
Endoderm
Partners
desarrollo
Hhex
TCF 1
Characterization of novel Hhex partners: SOX13 and c-Myc. New mechanism for the regulation of Wnt/TCF and c-Myc pathways