Now showing items 10-29 of 107

    Biological function of SLIMP, a mitochondrial seryl-tRNA synthetase paralog 

    Picchioni, Daria (Date of defense: 2014-10-23)

    Our research group focuses on protein translation and more specifically on the mechanism of transfer RNA (tRNA) aminoacylation by a family of essential and universal enzymes called aminoacyl-tRNA synthetases (aaRSs). aaRS ...

    Biophysical study of the aggregation of the androgen receptor protein in spinal bulbar muscular atrophy 

    Chiesa, Giulio (Date of defense: 2015-12-11)

    Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the ...

    Biotechnological approaches to cardiac differentiation of human induced pluripotent stem cells 

    Di Guglielmo, Claudia (Date of defense: 2016-02-09)

    The heart can be considered the most important organ of our body, as it supplies nutrients to all the cells. When affected from injuries or diseases, the heart function is hampered, as the damaged area is substituted by a ...

    Búsqueda de nuevas estrategias y agentes terapéuticos en enfermedades metabólicas hereditarias 

    Matalonga Borrel, Lesley (Date of defense: 2016-04-15)

    Los trastornos lisosomales y la aciduria glutárica tipo I son las enfermedades objeto de este estudio. Dichas enfermedades, pertenecen al numeroso grupo de enfermedades metabólicas hereditarias (EMH) y tienen en común la ...

    Caracterització epigenètica dels elements Alu i el seu paper en la regulació transcripcional 

    Martín Abad, Berta (Date of defense: 2013-12-13)

    L’epigenètica fa referència als canvis heretables en l'expressió gènica que no són causats per alteracions en la seqüència d'ADN. La metilació de la citosina en el dinucleòtid CpG és una de les modificacions epigenètiques ...

    Caracterización molecular y funcional de Small-Ubiquitin-related MOdifier en Arabidopsis thaliana 

    Castaño Miquel, Laura (Date of defense: 2015-01-30)

    SUMO, Small Ubiquitin-related MOdifier, es un modificador post-traduccional de la familia de la Ubiquitina, ya que presentan estructuras y mecanismo de conjugación conservados. La unión de SUMO al sustrato puede modificar ...

    Cell death and cytokine-mediated inflammatory responses to glucose deprivation in cancer cells 

    Püschel, Franziska (Date of defense: 2019-10-31)

    Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells are more dependent on glucose compared to non-transformed tissue. Targeting the cancer metabolism opens up a new strategy ...

    Combinatorial perspective on the gene expression circuits established by the CPEB-family of RNA binding proteins 

    Duran Arqué, Berta (Date of defense: 2020-12-21)

    The complex changes that take place in the mature Xenopus oocyte and early embryo are orchestrated in the absence of transcription. Until zygotic transcription starts, after the mid-blastula transition, cells ...

    Connecting centrosomes, cilia and the DNA damage response 

    Terré Torras, Berta (Date of defense: 2016-12-13)

    The suppression of genome instability by the DNA damage response (DDR) is critical for preventing human diseases characterized by developmental defects, infertility and in some cases, elevated cancer predisposition. After ...

    Contribución al conocimiento de la acarofauna de los micromamíferos de la región catalana 

    Gállego Culleré, M. (Montserrat) (Date of defense: 1986-01-01)

    El desconocimiento generalizado de nuestra base de trabajo, la acarofauna, conlleva que, como paso previo a cualquier otro estudio, deba procederse primariamente a la tarea mucho más ingrata, y a veces poco reconocida, de ...

    Contribución al estudio de la micoflora presente en el hábitat de animales aparentemente sanos 

    Abarca Salat, Maria Lourdes (Date of defense: 1986-01-01)

    La célula animal puede ser parasitada por un amplio grupo de hongos miceliares y levaduras que desencadenan procesos clínicos característicos: dermatofitosis, micosis profundas, etc. Estos microorganismos han sido objeto ...

    Control del estado de fosforilación de la glucógeno sintasa de hepatocitos de rata 

    Ariño Carmona, Joaquín (Date of defense: 1986-01-01)

    Uno de los tipos más interesantes de modificación covalente post-traduccional es la fosforilación de proteínas. Su importancia reside, en que afecta a numerosas vías metabólicas celulares, por lo general a través de los ...

    CPEB2 in mammary gland homeostasis and breast cancer 

    Pascual Domingo, Rosa (Date of defense: 2018-07-03)

    The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary gland is hierarchically ...

    Delivery of SN-38 in pediatric solid tumors 

    Monterrubio Martínez, Carles (Date of defense: 2016-11-17)

    A new combined microdialysis – tumor homogenate method for the determination of compartmental (vascular, extra- and intracellular) SN-38 distribution in patient-derived xenografts (PDX) generated from pediatric solid tumors ...

    Desarrollo de modelos celulares para estudios terapéuticos en la enfermedad de Alzheimer 

    Molina Martínez, Patricia (Date of defense: 2016-02-09)

    La enfermedad de Alzheimer (EA) es la causa más común de demencia neurodegenerativa en los países desarrollados y su prevalencia aumenta con la edad. Los genes cuyas mutaciones son responsables de EA familiar son APP, PSEN1 ...

    Design, synthesis and biological evaluation of new polymer-drug conjugates based on polyglutamic acid and 5-Fluorouracil for the treatment of advanced colorectal cancer 

    Plà Solans, Helena (Date of defense: 2014-11-13)

    Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment involves high doses of ...

    Development and optimization of high-performance computational tools for protein-protein docking 

    Jiménez García, Brian (Date of defense: 2016-07-21)

    Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of dealing with huge amounts ...

    Development of a biomimetic mechanical stimulation system to improve the maturation of human iPS-derived myocardial grafts 

    Crespo Santiago, Juan (Date of defense: 2016-07-21)

    La ingeniería tisular cardíaca ha evolucionado rápidamente en los últimos años, desde los primeros ensayos con diferentes especies animales hasta la producción de la primera generación de tejidos cardíacos humanos que ...

    Development of Organocatalytic Tandem Processes for the Asymmetric Synthesis of Nitrogen-Containing Compounds 

    Parra Montes, Claudio (Date of defense: 2015-07-17)

    En esta tesis se desarrolla una metodología general para la construcción tándem de manera asimétrica de importantes “building blocks” que se encuentran presentes en la estructuras de muchos productos naturales complejos y ...

    Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy 

    Moles Meler, Ernest (Date of defense: 2015-12-09)

    Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC ...