Now showing items 15-34 of 116

    Capsaspora owczarzaki as a unicellular model to study the pre-metazoan integrin adhesome 

    Parra Acero, Helena (Date of defense: 2019-02-08)

    Animal multicellular structure depends on three general mechanisms: cell adhesion, cell communication and cell differentiation. Some of these mechanisms were thought to be specific to animals. Genome sequencing of unicellular ...

    Caracterización del mecanismo molecular por el cual la vía WNT/Bcatenina especifica el eje anteroposterior y controla la organogénesis en las planarias 

    Sureda Gómez, Miquel (Date of defense: 2017-09-15)

    La vía Wnt canónica es una vía de señalización muy conservada a lo largo de la evolución de los animales. Esta vía controla múltiples procesos como es la especificación del eje anteroposterior o el destino celular durante ...

    Characterization of emerging novel human astrovirus: form bedside to bench 

    Vu Cantero, Diem-Lan (Date of defense: 2020-01-20)

    Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...

    Characterization of genetic factors associated with melanoma susceptibility and prognosis 

    Potrony Mateu, Míriam (Date of defense: 2018-09-28)

    Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur in a familial context. ...

    Chitin deposition in the apical extracellular matrices of Drosophila melanogaster: a focus on Expansion, Rebuf and Chitin Synthases 

    De Giorgio, Ettore (Date of defense: 2022-03-18)

    Chitin has a recognised importance in physiology but also as a biomaterial. In insects, it is the principal component of the apical extracellular matrix of epidermis, tracheae, foregut and hindgut. In these compartments, ...

    Combining exome sequencing and functional studies to identify causal genes of ultra-rare neurodevelopmental disorders 

    Castilla-Vallmanya, Laura (Date of defense: 2021-11-04)

    Neurodevelopmental disorders (NDDs) are a group of chronic diseases in which the development of the central nervous system is impaired, resulting in disability at the neuropsychiatric, motor and/or intellectual level. Some ...

    Conservation of different mechanisms of Hox cluster regulation within chordates 

    Herrera Úbeda, Carlos (Date of defense: 2019-12-16)

    In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an example of these ...

    Control strategies and gene expression dynamics of the plant pathogen Ralstonia solanacearum = Estratègies de control i dinàmica d'expressió gènica en el fitopatogen Ralstonia solanacearum 

    Puigvert Sànchez, Marina (Date of defense: 2018-06-05)

    The plant pathogen Ralstonia solanacearum is the causal agent of bacterial wilt, a highly aggressive disease responsible for important worldwide economic losses. Many virulence factors in R. solanacearum have been already ...

    CRP-cAMP mediated silencing of virulence expression in Salmonella enterica serovar Typhimurium 

    El Mouali Benomar, Youssef (Date of defense: 2017-09-15)

    The regulation of the expression of virulence genes in Salmonella enterica serovar Typhimurium is an intensively studied feature of Salmonella lifestyle. How Salmonella integrates environmental signals to activate ...

    Data Driven Approach to Enhancing Efficiency and Value in Healthcare 

    Guerrero Ludueña, Richard E. (Date of defense: 2017-09-07)

    Healthcare is changing, and the era of data-driven healthcare organisations is increasingly popular. Data-Driven approaches (e.g., Machine Learning, Metaheuristics, Modelling and Simulation, Data Analytics, and Data ...

    Deconstruction of the cardiopharyngeal gene regulatory network in appendicularians, a paradigmatic study of Oikopleura dioica as an evolutionary knockout model 

    Ferrández Roldán, Alfonso (Date of defense: 2021-02-22)

    The bloom of genomic data has revealed a vast amount of gene losses across all life kingdoms. However, the impact of gene loss on the evolution of the mechanisms of embryo development remains an important challenge. In ...

    Del cicle biològic a noves estratègies vacunals pel virus de l’hepatitis A 

    Chavarria Miró, Gemma (Date of defense: 2023-10-30)

    [cat] El virus de l'hepatitis A (HAV) s'allibera de cèl·lules infectades principalment embolcallat en membranes de la pròpia cèl·lula, formant partícules quasi embolcallades (eHAV). Es creu que la biogènesis d’eHAV podria ...

    Desarrollo de métodos rápidos para la detección de bacteriófagos como indicadores de contaminación fecal 

    Toribio Avedillo, Daniel (Date of defense: 2021-07-23)

    El control de la transmisión de patógenos víricos a través de la ruta fecal-oral ha adquirido recientemente relevancia e interés público. Para mantener este control, es necesario determinar indicadores apropiados para la ...

    Desarrollo de técnicas bioinformáticas para el análisis de datos de secuenciación masiva en sistemática y genómica evolutiva: Aplicación en el análisis del sistema quimiosensorial en artrópodos 

    Frías López, Cristina (Date of defense: 2019-11-29)

    Las tecnologías de secuenciación de próxima generación (NGS) proporcionan datos potentes para investigar cuestiones biológicas y evolutivas fundamentales, como estudios relacionados con la genómica evolutiva de la adaptación ...

    Desarrollo y utilización de herramientas bioinformáticas en el estudio de datos de secuenciación masiva: Análisis genómicos en arácnidos. 

    Sánchez Herrero, José Francisco (Date of defense: 2019-12-13)

    Encontramos una gran cantidad de información genómica en bases de datos para numerosos organismos pero existe un sesgo hacia ciertos grupos taxonómicos por el interés económico, social o sanitario. Los avances y el ...

    Desinfecció electroquímica d'aigües residuals per processos d'oxidació avançada 

    Bruguera Casamada, Carmina (Date of defense: 2018-11-09)

    Els mètodes electroquímics s’estan estudiant com a mètodes alternatius pel tractament de l’aigua amb la finalitat d’eliminar-ne els contaminants, tant els microbiològics com els químics, en qualsevol punt del cicle de ...

    Detección y caracterización de virus emergentes en su ciclo ambiental 

    Blanco Ortiz, Albert (Date of defense: 2021-09-07)

    Besides classic enteric viruses such hepatitis A virus and norovirus, there are other viruses that can reach water sources without being part of their transmission route. Some of these pathogens are enveloped viruses, which ...

    Determinación de la contaminación microbiológica del agua de riego aplicando nuevas estrategias de análisis 

    Cárdenas Youngs, Yexenia I. (Date of defense: 2018-06-20)

    Esta tesis doctoral tuvo como objetivo principal identificar y cuantificar la presencia de bacterias patógenas, mediante el uso de indicadores de contaminación fecal y Legionella en aguas de riego aplicando métodos ...

    Determining the Three-dimensional Structure of Genomes and Genomic Domains Integrating Chromosome Conformation Capture Data and Microscopy Images 

    Castillo Andreo, David (Date of defense: 2023-03-01)

    [eng] Microscopy and Chromosome Conformation Capture (3C) are the two main techniques for studying the three-dimensional (3D) organization of the genome. Microscopy, allowing the visualization of genomic loci in individual ...

    Development and regeneration of Drosophila wing imaginal discs: the role of IncRNAs and the stress sensor D-GADD45 

    Camilleri Robles, Carlos (Date of defense: 2022-07-22)

    Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that lack protein-coding potential. Although multiple examples of functional lncRNAs have been described, particularly regulating gene ...