Universitat de Barcelona
Now showing items 21-40 of 115
During early development of bilaterian animals, specific body structures are formed and body axes are established. The establishment of body axes requires the precise and coordinated function of signalling pathways and ...
The regulation of the expression of virulence genes in Salmonella enterica serovar Typhimurium is an intensively studied feature of Salmonella lifestyle. How Salmonella integrates environmental signals to activate ...
La vía Wnt canónica es una vía de señalización muy conservada a lo largo de la evolución de los animales. Esta vía controla múltiples procesos como es la especificación del eje anteroposterior o el destino celular durante ...
This thesis is focused in the identification and improvement of lipases for biotechnological application. The importance of lipases is increasing in several industries. However, the commercial use of lipases is still a ...
Osteoporosis is a general skeletal disorder. It is characterized by a low bone mass and a microarchitectural deterioration of bone tissue, which increase bone fragility and susceptibility to fracture. LRP5 is a widely ...
Osteoarthritis (OA) is a multifactorial disease characterized by a progressive degeneration and eventual failure of the synovial joint functionality. Although it has been traditionally considered as an exclusive disease ...
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific regulation in ...
Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...
El establecimiento de conexiones sinápticas específicas entre neuronas es esencial para la formación de los circuitos neuronales. En muchos sistemas esto requiere de una extensión hacia una capa sináptica concreta y la ...
The tracheal (respiratory) system of the Drosophila embryo is a network of interconnected epithelial tubes that supplies and exchanges the gas to maintain the homeostasis of the entire organism. Maintaining a controlled ...
Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Using variant-specific antibodies to H1 and hemagglutinin-tagged recombinant H1 variants expressed in breast ...
Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...
Tanto los genes de resistencia a antibióticos (ARGs) como algunos genes de virulencia son movilizados entre las poblaciones bacterianas por elementos genéticos móviles (MGE). La transferencia horizontal de genes (HGT) está ...
El gen MC1R (codi OMIM: #155555) codifica pel receptor de la melanocortina 1 (MC1R) que s’expressa majoritàriament a la membrana dels melanòcits i està implicat en la regulació de la síntesi de melanina. El gen MC1R és ...
The plant pathogen Ralstonia solanacearum is the causal agent of bacterial wilt, a highly aggressive disease responsible for important worldwide economic losses. Many virulence factors in R. solanacearum have been already ...
The hypersensitive response (HR) is a paradigmatic type of programmed cell death, that occurs in response to pathogen recognition at the site of attempted invasion. Notwithstanding more than a century of research on HR, ...
Esta tesis doctoral tuvo como objetivo principal identificar y cuantificar la presencia de bacterias patógenas, mediante el uso de indicadores de contaminación fecal y Legionella en aguas de riego aplicando métodos ...
El creixent nombre de genomes seqüenciats està posant de manifest que la pèrdua gènica és un fenomen recurrent que pot haver generat diversitat al llarg de la història evolutiva dels diferents grups d’organismes. En aquest ...
El virus de l’hepatitis A (HAV), el prototip del gènere Hepatovirus, té una sèrie de característiques que el diferencien de la resta de membres de la família Picornaviridae. Entre aquestes, la via de sortida descrita ...
Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur in a familial context. ...
