Now showing items 21-40 of 115

    Conservation of different mechanisms of Hox cluster regulation within chordates 

    Herrera Úbeda, Carlos (Date of defense: 2019-12-16)

    In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an example of these ...

    Control strategies and gene expression dynamics of the plant pathogen Ralstonia solanacearum = Estratègies de control i dinàmica d'expressió gènica en el fitopatogen Ralstonia solanacearum 

    Puigvert Sànchez, Marina (Date of defense: 2018-06-05)

    The plant pathogen Ralstonia solanacearum is the causal agent of bacterial wilt, a highly aggressive disease responsible for important worldwide economic losses. Many virulence factors in R. solanacearum have been already ...

    CRP-cAMP mediated silencing of virulence expression in Salmonella enterica serovar Typhimurium 

    El Mouali Benomar, Youssef (Date of defense: 2017-09-15)

    The regulation of the expression of virulence genes in Salmonella enterica serovar Typhimurium is an intensively studied feature of Salmonella lifestyle. How Salmonella integrates environmental signals to activate ...

    Data Driven Approach to Enhancing Efficiency and Value in Healthcare 

    Guerrero Ludueña, Richard E. (Date of defense: 2017-09-07)

    Healthcare is changing, and the era of data-driven healthcare organisations is increasingly popular. Data-Driven approaches (e.g., Machine Learning, Metaheuristics, Modelling and Simulation, Data Analytics, and Data ...

    Deconstruction of the cardiopharyngeal gene regulatory network in appendicularians, a paradigmatic study of Oikopleura dioica as an evolutionary knockout model 

    Ferrández Roldán, Alfonso (Date of defense: 2021-02-22)

    The bloom of genomic data has revealed a vast amount of gene losses across all life kingdoms. However, the impact of gene loss on the evolution of the mechanisms of embryo development remains an important challenge. In ...

    Del cicle biològic a noves estratègies vacunals pel virus de l’hepatitis A 

    Chavarria Miró, Gemma (Date of defense: 2023-10-30)

    [cat] El virus de l'hepatitis A (HAV) s'allibera de cèl·lules infectades principalment embolcallat en membranes de la pròpia cèl·lula, formant partícules quasi embolcallades (eHAV). Es creu que la biogènesis d’eHAV podria ...

    Desarrollo de métodos rápidos para la detección de bacteriófagos como indicadores de contaminación fecal 

    Toribio Avedillo, Daniel (Date of defense: 2021-07-23)

    El control de la transmisión de patógenos víricos a través de la ruta fecal-oral ha adquirido recientemente relevancia e interés público. Para mantener este control, es necesario determinar indicadores apropiados para la ...

    Desarrollo de técnicas bioinformáticas para el análisis de datos de secuenciación masiva en sistemática y genómica evolutiva: Aplicación en el análisis del sistema quimiosensorial en artrópodos 

    Frías López, Cristina (Date of defense: 2019-11-29)

    Las tecnologías de secuenciación de próxima generación (NGS) proporcionan datos potentes para investigar cuestiones biológicas y evolutivas fundamentales, como estudios relacionados con la genómica evolutiva de la adaptación ...

    Desarrollo y utilización de herramientas bioinformáticas en el estudio de datos de secuenciación masiva: Análisis genómicos en arácnidos. 

    Sánchez Herrero, José Francisco (Date of defense: 2019-12-13)

    Encontramos una gran cantidad de información genómica en bases de datos para numerosos organismos pero existe un sesgo hacia ciertos grupos taxonómicos por el interés económico, social o sanitario. Los avances y el ...

    Desinfecció electroquímica d'aigües residuals per processos d'oxidació avançada 

    Bruguera Casamada, Carmina (Date of defense: 2018-11-09)

    Els mètodes electroquímics s’estan estudiant com a mètodes alternatius pel tractament de l’aigua amb la finalitat d’eliminar-ne els contaminants, tant els microbiològics com els químics, en qualsevol punt del cicle de ...

    Detección y caracterización de virus emergentes en su ciclo ambiental 

    Blanco Ortiz, Albert (Date of defense: 2021-09-07)

    Besides classic enteric viruses such hepatitis A virus and norovirus, there are other viruses that can reach water sources without being part of their transmission route. Some of these pathogens are enveloped viruses, which ...

    Determinación de la contaminación microbiológica del agua de riego aplicando nuevas estrategias de análisis 

    Cárdenas Youngs, Yexenia I. (Date of defense: 2018-06-20)

    Esta tesis doctoral tuvo como objetivo principal identificar y cuantificar la presencia de bacterias patógenas, mediante el uso de indicadores de contaminación fecal y Legionella en aguas de riego aplicando métodos ...

    Determining the Three-dimensional Structure of Genomes and Genomic Domains Integrating Chromosome Conformation Capture Data and Microscopy Images 

    Castillo Andreo, David (Date of defense: 2023-03-01)

    [eng] Microscopy and Chromosome Conformation Capture (3C) are the two main techniques for studying the three-dimensional (3D) organization of the genome. Microscopy, allowing the visualization of genomic loci in individual ...

    Development and regeneration of Drosophila wing imaginal discs: the role of IncRNAs and the stress sensor D-GADD45 

    Camilleri Robles, Carlos (Date of defense: 2022-07-22)

    Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that lack protein-coding potential. Although multiple examples of functional lncRNAs have been described, particularly regulating gene ...

    Development and validation of a sequencing panel for translocations, copy number alterations and mutations with clinical relevance in mature B-cell neoplasms 

    Gómez Llonin, Andrea (Date of defense: 2021-04-30)

    The application of NGS techniques to the study of mature B-cell neoplasms at the research level is providing a large amount of new information, in certain cases with clinical implications, which includes the identification ...

    Dimensionality reduction in multigroup data: applications in integrative omics 

    Millapán Toledo, Carolina Andrea (Date of defense: 2023-12-18)

    [eng] The idea of this research is to propose dimensionality reduction methods considering multi- groups in a dataset. In multivariate analysis, there are many multigroup methods, but they have different objectives than ...

    Dissercting the activities of Capicua, Dorsal and Groucho in Drosophila dorsoventral patterning 

    Papagianni, Aikaterini (Date of defense: 2017-09-14)

    During early development of bilaterian animals, specific body structures are formed and body axes are established. The establishment of body axes requires the precise and coordinated function of signalling pathways and ...

    Diversitat bacteriana a les etapes de potabilització de les aigües de consum 

    Pinar Méndez, Anna (Date of defense: 2022-09-30)

    En els darrers anys l’augment poblacional així com els efectes d’un escalfament global estan minvant la capacitat i la qualitat dels recursos hídrics naturals disponibles. Els reptes als que ens enfrontem donen pas al ...

    Diversitat de comunitats heteròtrofes associades a les aigües de consum 

    Sala Comorera, Laura (Date of defense: 2016-12-14)

    Els indicadors microbians de la contaminació fecal han estat útils al llarg dels anys pel control sanitari de la qualitat de l’aigua de consum. Tot i així, l’aigua mineral embotellada i l’aigua de la xarxa de distribució ...

    Drosophila CIC-a: A chloride channel required in the glial niche for neural development 

    Plazaola Sasieta, Haritz (Date of defense: 2018-11-29)

    The chloride channel ClCN2 is expressed in glia in the mature nervous system of vertebrates and some physiological functions have been proposed. In addition, human patients with mutations in the gene or dysfunction of the ...