Study of the Influence of a Combination of Pharmacogenetic Variables on Tacrolimus Exposure: A Population Pharmacokinetic Approach 

Andreu Solduga, Franc (Fecha de defensa: 2017-09-29)

The calcineurin inhibitor Tacrolimus (Tac) is used to prevent acute rejection after renal transplant. Unfortunately, the clinical use of Tac is complicated by its considerable toxicity, narrow therapeutic window, and high ...