Biomedical studies of human adenosine deaminase acting on transfer RNA and related therapeutic strategies 

    Roura Frigolé, Helena (Date of defense: 2018-07-27)

    Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...

    Characterization of the functional connection between the BROMODOMAIN and EXTRATERMINAL DOMAIN PROTEIN 9 (BET9) and the circadian clock in Arabidopsis thaliana 

    Maric, Aida (Date of defense: 2021-11-05)

    The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...

    Estudi de les funcions reguladores de les regions transcrites ultraconservades (T-UCRs) sobre l’expressió gènica 

    Soler Riera, Marta (Date of defense: 2023-02-24)

    [cat] Els RNAs no codificants tenen un paper important com a reguladors de les funcions biològiques del desenvolupament i la fisiologia, i per tant la seva desregulació pot tenir un impacte en diverses patologies. Estan ...

    Functional analysis of a phloem cysteine protease in Arabidopsis thaliana 

    Pitsili, Eugenia (Date of defense: 2021-11-04)

    Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite diverse, from ...

    Identificación y caracterización de nuevos defectos del metabolismo energético mitocondrial asociados a aciduria 3-metilglutacónica y a deficiencia del complejo I 

    Ugarteburu López, Olatz (Date of defense: 2021-09-30)

    Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas de “Next generation ...

    Identifying molecular mechanisms that determine resistance to CDK4/6 inhibitors in HER2-enriched advanced luminal breast cancer 

    Gregorio Jordán, Sara (Date of defense: 2021-12-03)

    Breast Cancer (BCa) is the most prevalent cancer among women worldwide. It is a very heterogeneous disease at the histological, molecular and clinical level. Consequently, different classifications are used for stratifying ...

    The impact of nutrients on clock genes and metabolism: their role for the prevention and treatment of metabolic diseases 

    Castillo Figueroa, Ana Lucía (Date of defense: 2017-04-24)

    A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes results in metabolic ...

    Interrelación entre la respuesta a sombra y la síntesis de carotenoides en Arabidopsis thaliana 

    Ortiz Alcaide, Miriam (Date of defense: 2017-05-10)

    Los carotenoides son pigmentos fotosintéticos con un papel esencial para la protección de los cloroplastos frente al daño fotooxidativo causado por el exceso de irradiación solar. Cuando las plantas crecen en alta densidad ...

    Mapping protein aggregation by deep mutational scanning 

    Seuma Areñas, Mireia (Date of defense: 2023-01-18)

    [eng] Proteins can adopt multiple conformations and material states, from soluble states to self- assemblies, such as liquid condensates or amyloids. Protein aggregation has been associated with many human diseases but how ...

    Regulación de las respuestas a la proximidad vegetal en Arabidopsis thaliana y especies afines 

    Molina Contreras, María José (Date of defense: 2017-09-18)

    El síndrome de huida de la sombra (Shade Avoidance Syndrome, SAS) se refiere al conjunto de respuestas de las plantas desencadenadas por la detección de la disminución de la razón entre luz roja (R) y roja lejana (FR) de ...

    The transcriptional regulator HDAC7 role in B cell development and associated malignancies 

    Meler Marquina, Ainara (Date of defense: 2023-06-29)

    [eng] Proper B cell identity demands a tight controlled genomic and epigenomic landscape at each stage of cellular differentiation during B lymphocyte development. It has been previously identified in our group that HDAC7 ...