Universitat de Barcelona
Now showing items 280-299 of 304
En Ia levadura de gemación el tamaño celular en START o tamaño crítico está determinado por Ia velocidad de crecimiento en G1. Durante esta fase, Saccharomyces cerevisiae presenta una disminución de Ia relación ...
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
[eng] Advances in structural and molecular biology have favoured the rational development of novel drugs thru structure-based drug design (SBDD). Particularly, computational tools have proven to be rapid and efficient tools ...
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution ...
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival rate of less than 20%, ...
In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ribosome biogenesis and ...
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute to histone deposition ...
[eng] Proper B cell identity demands a tight controlled genomic and epigenomic landscape at each stage of cellular differentiation during B lymphocyte development. It has been previously identified in our group that HDAC7 ...
Lipophilicity is a key physicochemical descriptor used to understand the biological profile of (bio)organic compounds, xenobiotics and a broad variety of biochemical, pharmacological, and toxicological processes. This ...
Intestinal epithelium is highly specialized tissue organized into crypt-villus units relevant for their effective barrier function and nutrient absorption. In the crypt units reside the proliferative intestinal stem cells ...
In this PhD thesis we have demonstrated that tris(triphenylphosphine)ruthenium(II) dichloride (RuCl2(PPh3)3) is a potent and versatile catalyst capable of achieving efficient different chemical transformations under microwave ...
Evidencias recientes han mostrado que los tumores sólidos pediátricos, incluidos el neuroblastoma y el meduloblastoma, albergan una baja cantidad de mutaciones genéticas recurrentes, pero presentan una proporción significativa ...
Breast cancer (BC) is the most common cancer in women and it represents the most common cause of cancer-‐related death in women worldwide1. Advances in early detection, prevention, risk stratification, and therapeutic ...
Obesity prevalence is higher in Down syndrome (DS) than in the general population. Beyond metabolic alterations, individuals with DS present increased impulsivity, a trait observed in obese people and in compulsive eaters ...
[eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...
In plants, the sterol biosynthetic pathway leads to the production of a complex mixture of end-products, among which β-sitosterol, stigmasterol, campesterol, and cholesterol are the most abundant ones. Stigmasterol, the ...
Chloroplasts provide plants with metabolic pathways that are unique among eu- karoytes, including the methylerythritol 4-phosphate pathway (MEP) for the pro- duction of isoprenoids essential for photosynthesis and plant ...
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...
