Universitat de Barcelona
Now showing items 139-158 of 308
Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas de “Next generation ...
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different transcriptional ...
INTRODUCTION: Pulmonary manifestations are the main cause of morbidity and mortality in more than 90 % of cystic fibrosis (CF) patients who exceed the neonatal period. The chronic immune-inflammatory process, exacerbated ...
Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, ...
Breast Cancer (BCa) is the most prevalent cancer among women worldwide. It is a very heterogeneous disease at the histological, molecular and clinical level. Consequently, different classifications are used for stratifying ...
[eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to interrogate the Drosophila ...
Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...
A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes results in metabolic ...
Las enfermedades cardiovasculares se desarrollan como consecuencia de la interacción entre factores genéticos y ambientales. Los factores de riesgo cardiovascular son una serie de condiciones que favorecen la aparición de ...
In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches in the quest of ...
El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de ...
It is widely known that the development of modern chemistry and the consequent world industrialization have improved our quality of life to unimaginable levels. However, these advances have come with a high cost, causing ...
INTRODUCCIÓN: La obesidad grave es una enfermedad crónica que se caracteriza por un exceso de grasa corporal, que condiciona un aumento de la morbimortalidad. La cirugía bariátrica es el tratamiento de elección cuando ha ...
INTRODUCCIÓN. La retinopatía de la prematuridad (Retinopathy of prematurity, ROP) es una vitreorretinopatía proliferativa que afecta a los recién nacidos prematuros y es una de las principales causas de ceguera infantil. ...
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth of structural information ...
Marine viruses are key components of marine microbial communities, as they influence the cellular abundances and the community structure of microbes, participate in their genetic exchange, and intervene in the ocean ...
Los carotenoides son pigmentos fotosintéticos con un papel esencial para la protección de los cloroplastos frente al daño fotooxidativo causado por el exceso de irradiación solar. Cuando las plantas crecen en alta densidad ...
Las enfermedades cardiovasculares son una de las principales causas de mortalidad y morbilidad a nivel mundial, apareciendo como consecuencia de la acumulación de diversos factores de riesgo, tanto genéticos como ambientales. ...
El envejecimiento de la población comporta una mayor necesidad de servicios de cuidado para las personas mayores y la necesidad de tener en cuenta parámetros alimentarios y de actividad física para asegurar una óptima ...
Signal transduction pathways are essential mechanisms that cells use to perform a myriad of biological processes that when aberrant, can cause serious diseases. Understanding the molecular basis of these pathways in detail ...
