Simple and double conjugates of peptides and oligonucleotides 

Agramunt Pi, Jordi (Date of defense: 2019-11-08)

2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides react in an ...