Universitat Pompeu Fabra: Recent submissions
Now showing items 21-40 of 3213
Cognitive and synaptic outcomes of targeting peripheral cannabinoid type-1 receptor: focus on naïve and intellectual disability mouse models
Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability disorders such as fragile ...
Understanding and targeting mitochondria to counteract cellular senescene: elucidation of novel senotherapies
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...
Role of polycomb-like proteins in mouse embryonic stem cell differentiation
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...
Uso de los cambios en el soporte ventilatorio no invasivo durante la insuficiencia respiratoria aguda hipoxémica
El soporte respiratorio no invasivo (SRNI) es utilizado ampliamente en los Servicios de Medicina Intensiva para el tratamiento de la Insuficiencia Respiratoria Aguda Hipoxémica (IRAH). A pesar de los múltiples estudios ...
Demographic inference in complex populations: the North African case
Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...
Uncertainty analysis of individual predictions and integrated safety assessments in toxicology
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the- art ...
Inhaled treatment and patient-reported outcomes in asthma
The general aim of this doctoral thesis was to examine the impact on persons with persistent asthma of inhaled treatment use and sociodemographic factors, in terms of patient-reported outcomes. To achieve this, a new ...
Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
The Hajar Mountains of Southeastern Arabia: a laboratory to understand how reptile diversity is generated, distributed and maintained in arid environments
This thesis provides new insights into the evolution of biodiversity in arid regions by exploring the patterns and drivers of reptile diversity in the Hajar Mountains of Southeastern Arabia. We first assemble a genomic ...
Exploring the frontiers of synthetic biology: modelling, characterization, and applications of genetics circuits
Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first section of this PhD ...
The price of deciding: balancing resource constraints for optimisation
Prendre decisions es un repte, i a la par un aspecte inevitable a les nostres vides. D’entre totes les opcions viables, hom ha de sotmetre a escrutini i avaluació les diverses alternatives en tant gestionant la frustració ...
Adaptations in cancer: a molecular and mechanistic rewiring
Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
Temporal resolution by multiomic approaches of acute myeloid leukemias
Acute myeloid leukemias (AMLs) are a type of cancer where undifferentiated myeloid cells abnormally proliferate. Such phenotype can be caused by the expression of chimeric proteins like PML-RARα and MLL-AF9. Many studies ...
Understanding the molecular basis of neuronal 3'UTR length-dependent mRNA sorting
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
Integration of genetic and chemical screens to discover targeted therapies for HNF1 A-deficient diabetes
HNF1A encodes a key transcription factor in insulin-secreting beta cells from pancreatic islets. Heterozygous mutations in HNF1A cause monogenic diabetes, and hypomorphic variants in HNF1A increase the risk for type 2 ...
Mitochondria-to-cytosol H2O2 fluxes in redox biology
Los efectos del H2O2 en la fisiología celular, como oxidante y como señalizador es un campo que aún esta en expansión. Para intentar desvelar como ocurren estos fenómenos, hemos utilizado sondas codificadas genéticamente ...
Long-term resilience of cultivation systems in Tigrai (Ethiopia): an integrated approach combining archaeobotany, ethnoarchaeology and ecological modelling
The present study expands our understanding of human-environment interactions in drylands throughout time, with a specific focus on the development of resilient agroecological systems based on Traditional Ecological ...
Poéticas opositivas del tardofranquismo: Una crítica histórica de las poéticas de Juan Benet, Rafael Sánchez Ferlosio, Carmen Martín Gaite, Juan Goytisolo y Manuel Vázquez Montalbán
El objetivo de esta investigación es describir y analizar como un fenómeno de conjunto el emerger de las reflexiones sobre el hecho literario que Juan Benet, Rafael Sánchez Ferlosio, Carmen Martín Gaite, Juan Goytisolo y ...
Corporeidades al límite: El cuerpo femenino como territorio fronterizo desde la práctica artística como investigación
En Corporeidades al límite. El cuerpo femenino como territorio fronterizo desde la práctica artística como investigación, planteo una aproximación teórico-práctica de la presentación y representación del cuerpo femenino ...
Los bastiones del Rey, el camino de la Patria: Guerra, control y pacificación en el Camino Real de Veracruz, 1762-1821
This proposal focuses on the study of the military roads implemented by the viceregal government after 1815, in the different segments of the Camino Real during the Mexican War of Independence. From this perspective, ...
