An in silico clinical trial platform based on systems biology approaches 

Jorba Argemí, Guillem (Date of defense: 2023-04-13)

El procés de descobriment i desenvolupament de fàrmacs (DDD) és costós tant econòmic com temporalment, i el qual resulta en nivells d'èxit molt reduïts. Una gran quantitat de compostos son analitzats i molts descartats en ...

An Integrative approach to the systematics and evolution of some selected reptile groups from Arabia 

Simó Riudalbas , Marc (Date of defense: 2018-07-20)

Until relatively recently, many groups of terrestrial reptiles were considered to contain only few species vastly distributed across the Arabian Peninsula. This was mostly the result of the apparent morphological uniformity ...

Analysis and visualization of multidimensional cancer genomics data 

Schroeder, Michael Philipp (Date of defense: 2014-11-21)

Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...

Analysis of brain dynamics using echo-state networks 

Ibáñez Soria, David (Date of defense: 2018-09-13)

In the last decade recurrent neural networks have revolutionized the field of artificial intelligence. Their cyclic connections provide them with memory and thus with the capability of modeling processes with temporal ...

Analysis of circulating RNAs for the early detection of complex diseases using liquid biopsy 

Cabús Fornas, Lluc (Date of defense: 2024-03-15)

RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...

Analysis of citizen participation in science : perceptions of the different actors involved 

Llorente Lope, Carolina (Date of defense: 2020-11-27)

The main objective of this thesis is to improve understanding of citizen participation in science in Spain. Specifically, it analyses the characteristics of current participatory practices and the opinions and attitudes ...

Analysis of co-ancestry links in modern and ancient human populations 

Ferrando-Bernal, Manuel (Date of defense: 2021-07-09)

The aim of this thesis is to apply Identity by Descent (IBD) methodology to identify ancestry connections among individuals from genetically similar populations. Recombination events diminish the likelihood to detect IBDs. ...

Analysis of ensemble expressive performance in string quartets: a statistical and machine learning approach 

Marchini, Marco (Date of defense: 2014-11-27)

Computational approaches for modeling expressive music performance have produced systems that emulate human expression, but few steps have been taken in the domain of ensemble performance. Polyphonic expression and ...

Analysis of genetic polymorphisms for statistical genomics: tools and applications 

Morcillo Suárez, Carlos (Date of defense: 2011-12-19)

New approaches are needed to manage and analyze the enormous quantity of biological data generated by modern technologies. Existing solutions are often fragmented and uncoordinated and, thus, they require considerable ...

Analysis of genetic variation in microrna-mediated regulation and the susceptibility to anxiety disorders 

Muiños Gimeno, Margarita (Date of defense: 2009-12-18)

We have investigated genetic variation in microRNA-mediated regulation as a susceptibility factor for anxiety disorders following two different approaches. We first studied two isoforms of the candidate gene NTRK3 by ...

Analysis of human genetic variation in candidate genes under positive selections on the human linage 

Moreno Estrada, Andrés (Date of defense: 2009-04-21)

Natural selection has played an important role in shaping human genetic variation, thus, finding variants that have been targeted by positive selection can provide insights about which genes influence human phenotypic ...

Analysis of human intracranial recordings for clinical and cognitive studies 

Vila-Vidal, Manel (Date of defense: 2021-09-30)

Intracranial electroencephalography (iEEG) is an invasive diagnostic procedure used in severe drug-resistant epilepsy patients that provides simultaneous recordings of multiple brain regions at a very high temporal resolution. ...

Analysis of human mobility for architecture and urban studies 

Yoshimura, Yuji (Date of defense: 2016-11-25)

The goal of this dissertation is to provide insights into spatial analysis for architecture and urban studies through examining human mobility in the built environment based on large-scale datasets. Three studies are ...

Analysis of interaction design and evaluation methods in full-body interaction for special needs: collaborative virtual environments for improving socialization in children with autism 

Crowell, Ciera (Date of defense: 2019-09-20)

This thesis is focused on the specific properties and evaluation of full-body interaction design of multi-user mixed reality environments to aid in intervention strategies for children with autism, to improve their ...

Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain 

Vázquez Echeverría, Citlali (Date of defense: 2008-12-18)

The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex threedimensional structure. To achieve this complexity, a tight ...

Analysis of multiple protein sequence alignments and phylogenetic trees in the context of phylogenomics studies 

Capella Gutiérrez, Salvador Jesús (Date of defense: 2012-11-16)

Phylogenomics is a biological discipline which can be understood as the intersection of the fields of genomics and evolution. Its main focuses are the analyses of genomes through the evolutionary lens and the understanding ...

Analysis of NFAT5 expression and activity in response to toll-like receptors 

Lunazzi, Giulia (Date of defense: 2013-06-06)

Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional regulators. We show ...

Analysis of the evolving clinical phenotype and molecular mechanisms in Williams-Beuren syndrome 

Palacios Verdú, María Gabriela (Date of defense: 2015-10-19)

Williams-Beuren syndrome is a neurocognitive disorder with multisystemic manifestations of variable expressivity caused by a 1.55-1.83 Mb at chromosomal band 7q11.23. In this thesis project we have characterized the 7q11.23 ...

Analysis of the international debate on the right to peace in the context of the human rights and intergovernmental bodies of the United Nations 

Fernández Puyana, David (Date of defense: 2014-05-27)

Since the inception of the United Nations in 1945 the international community has been actively engaged in the promotion and strengthening of world peace through the adoption of different peace laws and resolutions. In ...

Analysis of transcription mechanisms that limit type I interferon responses 

Huerga Encabo, Hector (Date of defense: 2018-11-16)