In vitro metabolism and drug-drug interaction potential of irosustat, a steroidal sulfatase inhibitor 

Ventura Ventanachs, Verònica (Date of defense: 2013-10-18)

Irosustat is a first-generation, irreversible, steroid sulfatase inhibitor currently in development for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that undergoes desulfamoylation ...