Universitat de Barcelona
Now showing items 98-113 of 113
The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in vitro phenotypic ...
L’enzim Carnitina palmitoïltransferasa 1 (CPT1) permet l’entrada dels àcids grassos de cadena llarga a la matriu mitocondrial per tal de ser degradats i utilitzats així com a substrat energètic. El malonil-CoA, primer ...
There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped by 15%; there is also ...
La resistencia a la insulina es un estado patológico que se define como la incapacidad del organismo de responder normalmente a las acciones de la insulina. Este estado está ligado a la obesidad, al estilo sedentario de ...
The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs are likely generated ...
This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...
Changes in diet and life style caused an alarming increase in the incidence of obesity, which is considered a major risk factor for the onset of the metabolic syndrome. One of the initial events in obesity is adipocyte ...
Picornaviridae are among the most diverse and oldest known viral families that include many important pathogens of humans and animals. They are small, icosahedral (+)ssRNA viruses, causing a variety of diseases, such as ...
ANTECEDENTES: Entre un 20-25% de pacientes con cáncer de mama y ovario muestran historia familiar de dicha enfermedad. Una porción de estos casos son debidos a mutaciones germinales en genes de predisposición conocidos y ...
[eng] Several proteases and their antagonistic protein or peptide inhibitors sparked researchers’ interest due to their potential as therapeutic targets. The present thesis, which compiles results obtained in three independent ...
Current lifestyle with high-energy diets and little exercise is triggering an alarming growth in obesity. Excess of adiposity is leading to severe increase in associated pathologies, such as insulin resistance, type ...
The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...
Nek9 is a NIMA-related kinase that is phosphorylated in mitosis and a small pool of it (5%) is activated at the centrosomes by a complex mechanism which has remained elusive until now. Nek6 and Nek7 bind to the C-terminal ...
Carnitine palmitoyl transferase 1 (CPT1) enzymes catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, thus facilitating the entry of long-chain fatty acids to the mitochondria, where they undergo β-oxidation. ...
In human there are 518 protein kinases reported and many of them are involved in several cellular processes and also in important pathologies. Kinases have a diverse specificity for the sequences they phosphorylate, and ...
The embryo in grasses, at grain maturity, comprises the embryonic axis and the scutellum. The scutellum is supposed to be the single cotyledon in the monocotyledoneus embryos and is attached to the embryo axis in the ...
