Now showing items 55-74 of 143

    Formació del motiu quàdruplex bi-loop amb oligonucleòtids lineals i aplicació a la ciclació assistida per motlle 

    Viladoms Claverol, Júlia (Date of defense: 2008-11-12)

    Els àcids nucleics poden existir a la natura en una varietat de formes estructurals potencialment rellevants per al funcionament i la regulació dels gens. Aquesta tesi doctoral versa sobre una estructura no canònica del ...

    From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes 

    Oller Salvia, Benjamí (Date of defense: 2015-05-18)

    Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...

    From phage display and venoms to protease-resistant peptides: Design of BBB-shuttles and peptides targeting EGF 

    Díaz Perlas, Cristina (Date of defense: 2018-03-07)

    Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) and as new BBB-shuttles, ...

    Funcionalització de superfícies amb lligands per a la seva interacció específica amb avidina i estreptavidina 

    Canal Barcala, Ivan (Date of defense: 2016-01-22)

    Se ha estudiado espectroscópicamente (UV-Vis, Raman, RMN) los equilibrios tautoméricos del ácido 2-(4'-hidroxifenilazo)benzoico (HABA) y el ácido 2-(4'-hidroxi-3',5'- dimetilfenilazo)benzoico. Estos equilibrios están ...

    Geoquímica orgànica de conques lacustres fòssils 

    Heras i Cisa, F. Xavier de las (Francesc Xavier) (Date of defense: 1989-02-27)

    La memòria té dos apartats diferenciats. Al primer es caracteritzen des del punt de vista estructural bio-marcadors (o fòssils moleculars) com ara hidrocarburs alifàtics, alicílics i aromàtics, compostos oxigenats (alcohols, ...

    Glycoprobes for capture and identification of lectins from biological sources 

    Defaus Fornaguera, Sira (Date of defense: 2014-06-20)

    Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated and that the ...

    Homoasociación de porfirinas solubles en agua 

    Escudero Rodríguez, Carlos (Date of defense: 2007-12-18)

    Esta tesis doctoral tiene como objetivo general el estudio de los procesos de agregación de porfirinas sulfonadas amfifílicas. <br/><br/>En el primer capítulo se presentan los trabajos dirigidos a la obtención de porfirinas ...

    Immunochemical diagnostic strategies based on Quorum Sensing 

    Montagut Cañete, Enrique José (Date of defense: 2021-02-04)

    The final goal of the thesis was to improve the diagnostic of infections caused by P. aeruginosa and S. aureus through a better understanding of the bacterial communication process known as Quorum Sensing (QS) and its ...

    Inhibidores de distintas ARNt sintetasas de Plasmodium falciparum como potenciales agentes antimaláricos 

    López Ibáñez, Alba (Date of defense: 2013-11-14)

    Para frenar la creciente resistencia del Plasmodium, el parásito causante de la malaria, se necesitan nuevos fármacos con modos de acción diferentes a los de los fármacos actualmente existentes. Esta tesis se centra en ...

    Intermolecular Pauson-Khad reaction: study of the regioselectivity, photochemistry of the adducts and synthetic applications 

    Khaizourane, Héléa (Date of defense: 2016-03-11)

    The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated [2+2+1] ...

    Linkers for bioconjugation 

    Ramos Tomillero, Iván (Date of defense: 2016-07-15)

    Cancer is a heterogeneous disease that represents one of the principal causes of mortality in developed countries. Due to the social and economic implications of this pathology, tremendous efforts have been making over the ...

    Lligands hemilàbils en la reacció de Pauson-Khand intermolecular i asimètrica 

    Solà i Oller, Jordi (Date of defense: 2006-12-20)

    La reacció de Pauson-Khand (PK) és formalment una cicloaddició 2+1+1 entre un alquè, un alquí i una molècula de monòxid de carboni per donar lloc a una ciclopentenona. Aquesta reacció està mediada per una espècie de cobalt ...

    Marcatge amb 15N de purines i disseny de nous inhibidors del VIH-I 

    Terrazas Martínez, Montserrat (Date of defense: 2006-07-13)

    En la present Tesi s'han intentat desenvolupar noves metodologies que permetin modificar les nucleobases puríniques dels nucleòsids amb dues intencions clarament diferenciades: d'una banda, el seu marcatge amb 15N, per tal ...

    Marine Natural Products. Synthesis and structure determination 

    Lorente Crivillé, Adriana (Date of defense: 2014-07-18)

    Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...

    Mayotlide: synthetic approaches and structural elucidation 

    Herraiz Cobo, Jesús (Date of defense: 2017-07-13)

    Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...

    Modified oligonucleotides for triple helix studies and for the obtention of structures with biomedical and technological interest 

    Alvira Torre, Margarita (Date of defense: 2010-10-25)

    Oligonucleotides are short fragments of DNA (10-100nt) which are of great interest because their applications in molecular biology, biomedicine and nanotechnology. As a result of their ability to base pairing, oligonucleotides ...

    Molecular recognition in gas phase: theoretical and experimental study of non-covalent protein-ligand complexes by mass-spectrometry 

    Dyachenko, Andrey (Date of defense: 2013-04-15)

    In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...

    Multifunctional self-stratified polyurethane-polyurea nanosystems for smart drug delivery 

    Rocas Alonso, Pau (Date of defense: 2016-02-25)

    This thesis, entitled "Multifunctional Self-stratified Polyurethane-Polyurea Nanosystems for Smart Drug Delivery" is structured as a compendium of publications, being organized around a methodological synthetic patent and ...

    A Multiplexed diagnostic approach for cardiovascular disease biomarkers 

    Colom Sanmartí, Glòria (Date of defense: 2016-01-28)

    In the course of this thesis, the optimal epitopes for the subsequent polyclonal rabbit antibody production for cTnI and NT-proBNP have been studied and chosen. cTnI and NT-proBNP are the most relevant cardio-specific ...

    N-Myristoylation-Dependent c-Src Interactions 

    Le Roux, Anabel-Lise (Date of defense: 2015-11-18)

    c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...