Menchon Najas, Cristina (Date of defense: 2011-06-09)
Embryonic stem cells (ESC) are derived from the inner cell mass (ICM) of the blastocyst and have the capacity for unlimited proliferation while retaining their potential to differentiate into a wide ...
Bakešová, Jana (Date of defense: 2012-06-01)
In this dissertation we studied the pharmacological and functional consequences of adenosine A2A receptor interaction with other proteins, as other neurotransmitter receptores localized in the human ...
Andreu Pérez, Pedro Antonio (Date of defense: 2012-03-12)
1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and ...
Costa i Torres, Meritxell (Date of defense: 2012-05-04)
Introduction Heteromeric amino acid transporters (HATs) are composed of a heavy subunit (rBAT or 4F2hc) and a light subunit (b0 + AT, ASC1, LAT1, LAT2, y + LAT1, y + LAT2 and xCT), joined by a disulfide ...
Flores Guri, Oscar (Date of defense: 2014-06-10)
This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: ...