Now showing items 6198-6217 of 11039

    Involvement of Alternative Splicing Regulation in Adipose Tissue Thermogenic Induction 

    Castellá Giner, Moisés (Date of defense: 2023-09-29)

    [emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...

    Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease 

    Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

    Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

    Involvement of photoinhibition and redox balance in acclimation and developmental processes of plants 

    Muñoz Roldán, Paula (Date of defense: 2020-04-24)

    Environmental constraints and developmental processes in plants can lead to light energy excess in chloroplasts by lowering the threshold at which light becomes saturating by a lack of electron acceptors in the light-processing ...

    Involvement of Polyamines in PAMP-triggered Immunity and Systemic Acquired Resistance (SAR). Extragenic Suppressors of Immune Hybrid Incompatibility 

    Liu, Changxin (Date of defense: 2020-10-29)

    The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered immunity in autoimmune ...

    Involvement of the Microtubule-Regulated RhoGEF GEF-H1 in the G12 family signaling pathways 

    Garrido Antequera, Georgina (Date of defense: 2014-09-16)

    Heterotrimeric G proteins are masters regulators of cell homeostasis. They coordinate the signaling between G protein coupled receptors (GPCRs) and their intracellular effectors. Heterotrimeric G proteins are composed of ...

    Ion beam synthesis of silicon-carbon structures and related materials 

    Calvo Barrio, Lorenzo (Date of defense: 1999-07-16)

    The goal of this dissertation is the study and characterisation of high dose Carbon (C) implantation processes into Silicon (Si) and related materials for the synthesis of Silicon Carbide (SiC). The attainment of ...

    iPSCs, CRISPR/Cas9 y protocolos de diferenciación basados en factores de transcripción para generar nuevos modelos neuronales y astrocíticos del síndrome de Sanfilippo 

    Benetó Gandia, Noelia (Date of defense: 2020-07-16)

    El objetivo general de esta tesis doctoral ha sido la generación de nuevos modelos celulares para el síndrome de Sanfilippo y su utilización para ensayar una aproximación terapéutica para esta enfermedad basada en el uso ...

    IRALIKU'K: La confrontación de los comunales. Etnografía e historia de las relaciones de propiedad en Goizueta 

    Montesinos Llinares, Lidia (Date of defense: 2013-12-16)

    Esta tesis, planteada inicialmente como un estudio de comunidad, presenta un estudio de caso sobre relaciones de propiedad en Goizueta; un pueblo euskaldun (vascófono) de unos 700 habitantes situado en el noroeste de ...

    IRBC-induced p53-dependent Cell Death in c-MYC-driven tumors mediated by loss of MCL1 

    Domostegui Fernández, Ana (Date of defense: 2019-12-05)

    The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies ...

    Irlanda y la guerra civil española. Nuevas perspectivas de estudio 

    Soler Parício, Pere (Date of defense: 2013-05-11)

    Enmarcada en el estudio de la reacción internacional y la participación extranjera en la guerra civil española, esta Tesis analiza la respuesta al conflicto que se dio en Irlanda. Tal y como ocurrió en el resto de países ...

    The Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: functional studies of new target mRNAs and pathological implications for novel IRE mutations 

    Luscieti, Sara (Date of defense: 2016-11-22)

    Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...

    Irreversibility and Criticality in the Biosphere 

    Pueyo Puntí, Salvador (Date of defense: 2003-03-25)

    This work is the result of a search for general (or nearly general) regularities at ecosystem level, and an exploration of their practical relevance in our relations with the environment.<br/>I began by adding some new ...

    Irrigation with Laser-Activated sodium hypochlorite: An antimicrobial alternative in endodontics 

    Betancourt Henríquez, Pablo Andrés (Date of defense: 2019-10-21)

    Bacteria and their sub-products are the main cause of the occurrence and perpetuation of endodontic infection. However, only a few bacterial species are seen as responsible of persistent endodontic infections, among them ...

    Irrumpir lo artístico, perturbar lo pedagógico: La Investigación Artística como espacio social de producción de conocimiento 

    Calderón García, Natalia (Date of defense: 2015-06-29)

    Irrumpir lo artístico, perturbar lo pedagógico: La Investigación Artística como espacio social de producción de conocimiento es una investigación conformada por dos partes: esta tesis y dos vídeos: En colaboración y ...

    Irrupció de les avantguardes a Sabadell (1939-1959), La 

    Lozano Moya, Rosendo (Date of defense: 2003-02-26)

    Els estudis generals realitzats sobre la història de l'art català encara no han profunditzat en la història de l'art local. L'apropament a "quan" i " com" van arribar les avantguardes del Segle XX a Sabadell són una forma ...

    Is the extracellular ATP a key in X-linked Charcot-Marie-Tooth disease and in inherited non-syndromic deafness? 

    Mas del Molino, Ezequiel (Date of defense: 2011-02-25)

    El ATP es una molécula ampliamente conocida por su papel en muchas funciones como la homeostasis celular, el mantenimiento de gradientes iónicos, el mantenimiento del pH en gránulos secretores, el almacenamiento energético, ...

    La isla de calor urbana de superficie y sus factores condicionantes: El caso del área metropolitana de Santiago 

    Sarricolea Espinoza, Pablo (Date of defense: 2012-10-05)

    Se ha sintetizado la información de las temperaturas de emisión superficial obtenidas mediante 53 imágenes del satélite Terra MODIS, aplicando para ello promedios anuales y estacionales de las temperaturas estandarizadas, ...

    Islet amylold in type 2 diabetes: The role of chaperones in endoplasmic reticulum stress and amyloid formation in pancreatic β-cell 

    Cadavez Trigo, Lisa (Date of defense: 2014-11-19)

    La disminución de la masa de célula ß pancreática y la función en la diabetes tipo 2 (T2D) se puede atribuir a una serie de factores estresantes experimentados por el islote durante el desarrollo y la progresión de la ...

    Isocyanide as a key functional group for the synthesis of biologically active compounds 

    Abás Prades, Sònia (Date of defense: 2018-05-31)

    The distinctive reactivity of isocyanides has been recognised as an advantageous characteristic for the formation of heterocyclic compounds. In the present manuscript new synthetic possibilities are explored involving the ...

    Isoformes de la lipoproteïna lipasa en humans. Variacions en l'alletament i en l'obesitat. 

    Badia Villanueva, Míriam (Date of defense: 2019-10-14)

    La lipoproteïna lipasa (LPL) és un enzim àmpliament distribuït a l’organisme i aquest fet li confereix un rol central en el metabolisme lipídic. La seva funció principal és la hidròlisi dels triacilglicèrids de les ...