Now showing items 2511-2530 of 11039
Leitner, Stefanie (Date of defense: 2013-12-20)
The general objective of this research was the design of polymeric cationic nanoparticles from nano-emulsions obtained by low-energy methods for biomedical applications. This general objective includes the preparation of ...
Dalmases Solé, Mariona (Date of defense: 2019-02-08)
The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...
Nicolini, Federica (Date of defense: 2022-12-02)
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. On the contrary, ...
Paulme, Camille (Date of defense: 2013-02-01)
The presence of volatile fragrant molecules is generally associated with a feeling of pleasantness or cleanness in consumer products. Because of their high volatilities, the perception of fragrances is limited over time. ...
Ruiz García, Marta (Date of defense: 2020-10-20)
In today’s society, people’s interest against health care is growing every day. On a health- concerned population, food supplements and nutraceuticals are products with an increasing interest among the global community. ...
Plà Solans, Helena (Date of defense: 2014-11-13)
Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment involves high doses of ...
Alqahtani, Abdulateef (Date of defense: 2023-10-25)
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
González Díez, Aleix (Date of defense: 2023-07-24)
[eng] G protein-coupled-receptors (GPCRs) are the largest family of membrane proteins and mediate important cellular responses. Metabotropic glutamate receptors (mGlu) belong to the Glutamate family/Class C GPCR. These ...
Guardiola Bagán, Salvador (Date of defense: 2017-09-15)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed to provide effective ...
Gómez Santacana, Xavier (Date of defense: 2016-05-13)
Metabotropic glutamate receptors (mGlu receptors) are class C GPCRs widely distributed through the CNS and considered pharmacological targets for neurologic disorders, such as neuropathic pain and Parkinson’s disease, ...
Solé Solé, Judith (Date of defense: 2022-06-03)
Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless to most people (such ...
Aguilà Avilés, David (Date of defense: 2013-06-07)
This thesis presents different strategies for the design of molecular complexes with the requirements to be used as two-qubit quantum gates. The approaches followed towards the preparation of potential qubit systems have ...
Diego Creixenti, Rosa (Date of defense: 2022-01-21)
Spin crossover (SCO) complexes and single-molecule magnets (SMMs) are promising prototypes that can reach magnetic bistability within the molecular scale required for data storage. Despite the extensive library of versatile ...
Grau Campistany, Ariadna (Date of defense: 2014-07-17)
The global emergence and spread of multidrug-resistant bacteria is an important public health issue. However, the antimicrobial pipeline remains unacceptably lean, in fact over the last 25 years, the number of antimicrobial ...
Sá Leal, Nuno José de (Date of defense: 2017-09-14)
O design surge, no contexto da União Europeia, associado à Inovação e, em conjugação com esta, como um forte suporte ao desenvolvimento sustentado da economia da UE e seus Estados Membros. Apesar desta postura das instituições ...
Hervés Carrete, Carmen (Date of defense: 2023-05-24)
[eng] The main objective of this dissertation has been to stablish a bridge between materials science and its fields of application. The scope of this thesis work, under this premise, is aimed towards understanding the ...
Estruch Manjón, Alejandro (Date of defense: 1994-01-01)
Uno de los hechos que están en el origen de buena parte de los conflictos sociales en la sociedad actual es la constatación de que los beneficios del crecimiento económico no se distribuyen entre todos los miembros de la ...
Espuelas Barroso, Sergio (Date of defense: 2011-11-04)
En este trabajo se construido una serie de gasto social en España, entre 1850 y 2005, que ha permitido obtener una visión de largo plazo sobre la evolución de la política social y situar la experiencia española en el ...
Obregón Gutiérrez, Noemí (Date of defense: 2014-01-31)
La OMS considera desigualdades en Salud, las diferencias, injustas y evitables, entre un grupo poblacional definido social, económica, demográfica o geográficamente, relacionadas con la salud. Son el resultado de las ...
Precioso Amorós, José Luís (Date of defense: 2005-09-30)
El descenso de la tasa de mortalidad, unido al aumento de la esperanza de vida, ha hecho incrementar hasta siete veces la cifra de personas mayores en los últimos sesenta años. Además, no sólo aumenta el número de mayores, ...