Now showing items 10137-10156 of 10972

    Tabaquisme i esport. Modificacions metabòliques, cardiopulmonars i subjectives durant l'exercici físic 

    Comella Cayuela, Agustí (Date of defense: 2002-12-20)

    Introducció: La nicotina causa una estimulació simpàtica per mitjà de mecanismes centrals i perifèrics. Els mecanismes mediats pel SNC inclouen l'activació dels quimioreceptors perifèrics, particularment els quimioreceptors ...

    Tabaquisme i tercera edat a Catalunya 

    Nebot i Adell, Carme (Date of defense: 1990-03-21)

    El presente estudio aporta datos al conocimiento del hábito tabáquico en Catalunya. Se trata de un estudio de prevalencia, realizado sobre una muestra de 1600 individuos, dividida en dos estratos, institucionalizados y no ...

    Tadeusz Kantor: La construcción del espacio escénico 

    Susmanscky Bacal, Silvia (Date of defense: 2014-12-10)

    Si bien nuestra primera intención fue dedicar el presente estudio a los maniquíes de Tadeusz Kantor, durante la etapa de investigación el foco centrado en ese particular objeto -que el artista consideraba marginal- se fue ...

    El taller de vitralls modernista Rigalt, Granell & Cia. (1890-1931) 

    Gil Farré, Núria (Date of defense: 2013-12-11)

    La tesi doctoral que aquí presentem té com a base de la investigació l’associació empresarial entre el vitraller Antoni Rigalt i Blanch i l’arquitecte Jeroni F. Granell i Manresa. La recerca té dos objectius principal, ...

    Tamaño crítico: efectos e implicaciones en crecimiento y ciclo celular 

    Vidal Miñano, Pedro Jesús (Date of defense: 2020-09-07)

    En Ia levadura de gemación el tamaño celular en START o tamaño crítico está determinado por Ia velocidad de crecimiento en G1. Durante esta fase, Saccharomyces cerevisiae presenta una disminución de Ia relación ...

    Target Therapy in Rhabdomyosarcoma: Discovering new targets and apportunities 

    Prada Varela, Estela Maria (Date of defense: 2021-11-05)

    Pediatric RMS is a developmental tumor that affects patients from birth to late adolescence. RMS tumorigenesis involves the stalk of embryological myogenic processes. Classically, two main subgroups of RMS have been defined ...

    Targeted therapies in CLL. New drugs against CLL recurrent mutations 

    Giménez Carabaza, Neus (Date of defense: 2019-11-15)

    Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western countries. It is currently an incurable disease. CLL is a B-lymphoid neoplasm in which the microenvironment plays a key role in the development ...

    Targeting Malaria Transmission: A Transdisciplinary Approach 

    Portugaliza, Harvie P. (Date of defense: 2020-12-16)

    To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...

    Targeting metabolic reprogramming associated to cancer cells: search of novel targets and combined therapies in cancer treatment 

    Tarrado Castellarnau, Miriam Neus (Date of defense: 2015-12-11)

    Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer ...

    Targeting mitochondrial metabolism in cancer: development and validation of PEPCK-M and PYCR1 inhibitors 

    Aragó Belenguer, Marc (Date of defense: 2022-06-30)

    [spa] La reprogramación metabólica es uno de los procesos que caracterizan el cancer. Estos cambios en el metabolismo de las células tumorales no solo permiten a las células obtener los metabolitos necesarios para su ...

    Targeting non-canonical p38 MAPK signalling: discovery and characterization of novel allosteric p38α inhibitors 

    González Velasco, Lorena (Date of defense: 2021-09-14)

    Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...

    Targeting of antileishmanial drugs produced by nanotechnologies 

    Pujals Naranjo, Georgina (Date of defense: 2007-12-14)

    The aim of this work is to develop an effective new MGA delivery system by means of nanotechnology for the treatment of leishmaniosis which could be administered by parenteral or oral route in a future. Moreover, for ...

    Targeting Plasmodium falciparum protein aggregation as a new antimalarial design strategy 

    Bouzón Arnáiz, Inés (Date of defense: 2022-11-11)

    [eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...

    Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis 

    Lantero Escolar, Elena (Date of defense: 2020-12-11)

    La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...

    Targeting the crosstalk between tumor cells and microenvironment: a new therapeutic approach for the treatment of lymphoid neoplasms 

    Vidal Crespo, Anna (Date of defense: 2017-04-28)

    In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...

    Targeting the disordered N-terminal domain of androgen receptor. Novel inhibitors tackling biomolecular condensation to treat late stage prostate cancer 

    Frigolé Vivas, Marta (Date of defense: 2020-09-23)

    [eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to proteins, otherwise ...

    Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease 

    Vasilopoulou, Foteini (Date of defense: 2021-09-21)

    The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...

    Targeting the TGF-beta pathway of cancer-associated fibroblasts in colorectal cancer metastasis 

    Badia Ramentol, Jordi (Date of defense: 2020-01-14)

    Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...

    Targeting tumor microenvironment crosstalk through GPCR receptors and PI3K pathway 

    Guerrero Hernández, Martina (Date of defense: 2019-02-19)

    The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...

    Task Complexity and L2 Narrative Oral Production 

    Gilabert Guerrero, Roger (Date of defense: 2005-01-21)

    This study explores the impact of manipulating Task Complexity simultaneously along both pre-task planning time and the degree of displaced, past time reference on L2 narrative oral production. By drawing on consolidated ...