Now showing items 2645-2664 of 11001

    Development of model-driven approaches for metabolic flux analysis and anticancer drug discovery 

    Foguet Coll, Carles (Date of defense: 2019-12-20)

    Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...

    Development of multifunctional polymeric nanoparticles by nano-emulsion templating as advanced nanocarriers targeting the blood-brain barrier 

    Fornaguera Puigvert, Cristina (Date of defense: 2015-01-21)

    Multifunctional polymeric nanoparticles (NP) represent a promising alternative for the treatment of neurodegenerative diseases using the intravenous route (i.v.). In current treatments, the effects of the intravenously ...

    Development of nanovectors for the targeted drug delivery of antimalarials 

    Urbán, Patricia (Date of defense: 2013-02-11)

    Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease, and the complexity of the life cycle of its causative agent, the protozoan Plasmodium ...

    Development of new antimicrobial peptides and peptidomimetics and mechanism of resistance to peptide antibiotics 

    Vila Farrés, Xavier (Date of defense: 2014-11-14)

    Nowadays in the world there is a very big problem associated with two factors related to each other. The first factor is the increase in the resistant of certain bacteria, especially the bacteria from the ESKPAE group. The ...

    Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications 

    Ghashghaei, Ouldouz (Date of defense: 2017-09-26)

    1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...

    Development of New Tools for the Synthesis of "Difficult Peptides" 

    Paradís Bas, Marta (Date of defense: 2015-05-15)

    The known as "difficult peptides", as well as those sequences that aggregate in solution, are some of those molecules with high applicability as nanomaterials or even in medicine field. This thesis has addressed to overcome ...

    The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis 

    Kennington, Stuart (Date of defense: 2020-12-21)

    This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...

    Development of novel EELS methods to unveil nanoparticle properties 

    Torruella Besa, Pau (Date of defense: 2019-04-26)

    [eng] The aim of this thesis has been two-fold. First, to develop new processing and analysis tools and strategies for extracting information from EELS data, and second, to apply the methods to different nanoparticle systems ...

    Development of novel electroactive nanofluids for flow cells 

    Rueda García, Daniel (Date of defense: 2020-09-15)

    Flow cells are on their way to become a key player for electrical energy storage (EES) thanks to their suitability as load-levelling devices thus contributing to the development of smart grid and to offset the intermittency ...

    Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis 

    Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)

    [eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...

    Development of numerical methods to determine the litospheic structure combining geopetential, litosthatic and heat transport equations. Application to the Gibraltar arc system. 

    Fullea Urchulutegui, Javier (Date of defense: 2008-01-25)

    Detailed modelling of the present-day lithospheric structure is of paramount importance to understand the evolution of the Earth in the context of plate tectonics. The objectives of this thesis are twofold: the development ...

    Development of optical tools for biological applications based on acousto-optic technology 

    Bola Sampol, Raúl (Date of defense: 2021-06-17)

    To ensure progress in the field of biomedicine and drug development, it is essential to keep improving the equipment needed to carry out most of the experiments. With better tools, scientists can be more efficient, increasing ...

    Development of Organocatalytic Tandem Processes for the Asymmetric Synthesis of Nitrogen-Containing Compounds 

    Parra Montes, Claudio (Date of defense: 2015-07-17)

    En esta tesis se desarrolla una metodología general para la construcción tándem de manera asimétrica de importantes “building blocks” que se encuentran presentes en la estructuras de muchos productos naturales complejos y ...

    Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy 

    Moles Meler, Ernest (Date of defense: 2015-12-09)

    Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC ...

    Development of RTP processing for kesterite solar cells 

    Hernández Martínez, Alejandro (Date of defense: 2019-11-26)

    This thesis is devoted to the development of new annealing strategies via Rapid Thermal Processing (RTP) for Earth-abundant Cu2ZnSn(Sx,Se1-x) (CZTSSe) kesterite solar cells, which show a clear consensus amongst the scientific ...

    Development of Statistical Methodology to Study the Incidence of Drug Use 

    Sánchez Niubó, Albert (Date of defense: 2014-01-28)

    This work aims to contribute methodologically in the epidemiology of drug use, particularly estimation of incidence. No incidence figures of drug use in Spain had ever been published, prior to those appearing in these ...

    Development of synthetic strategies for lasso peptides with anticancer activity 

    Martín Gómez, Helena (Date of defense: 2018-02-23)

    Nowadays, the discovery and development of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules is of special interest. This has partially prompted ...

    Development of tunable bioinks to fabricate 3D-printed in vitro models: a special focus on skeletal muscle models with potential applications in metabolic alteration studies 

    García Lizarribar, Andrea (Date of defense: 2022-01-28)

    In vitro engineered three-dimensional tissue models are attracting an increasing interest due to their potential applications in preclinical assays. On the one hand, they are an alternative to the high costs, ethical issues ...

    Development Patterns in Multi-Sector Growth Models 

    Cruz González, Bernabé Edgar (Date of defense: 2016-01-15)

    Common patterns of structural change in the sectoral composition of production, consumption and labor force are observed across countries during the economic development process. These patterns of change consist mainly of ...

    Development, implementation, and validation of a new method for meta-analysis of voxel-based neuroimage studies 

    Albajes-Eizagirre, Anton (Date of defense: 2021-06-17)

    [eng] The objective of this thesis was to develop a method for the meta-analysis of neuroimaging studies that overcomes the drawbacks of the neuroimaging meta-analytic methods described above. To this end, we modified ...