Now showing items 2491-2510 of 11001

    Design and Synthesis of Bifunctional Compounds for Targeted Protein Degradation and Phosphorylation 

    Loren Parrondo, Guillem (Date of defense: 2023-09-15)

    [eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing the phosphorylation ...

    Design and synthesis of engineered peptides to target undruggable PPIs: from in silico to in vitro studies 

    Rivas Santos, Pep (Date of defense: 2019-12-10)

    Major unsolved diseases such as Cancer, cardiopathies or neurodegenerative disorders are frequently related with the malunction of complex protein networks. These networks are integrated by the interaction of multiple ...

    Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition 

    Lizano Gispert, Enric (Date of defense: 2020-07-24)

    This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...

    Design and synthesis of new potentially inhibitors of PCSK9 and KRAS proteins 

    Vilaplana Saiz, Marta (Date of defense: 2021-01-22)

    This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in ...

    Design and synthesis of peptides that neutralize bacterial endotoxins as therapeutic agents for the treatment of sepsis 

    Mas Moruno, Carlos (Date of defense: 2009-03-05)

    La sepsis es un síndrome muy complejo de definir, diagnosticar y tratar. La patología de la sepsis se deriva de una respuesta perjudicial del organismo a una infección. La exposición a endotoxinas bacterianas induce una ...

    Design and synthesis of photoswitchable coordination complexes 

    Salinas Uber, Jorge (Date of defense: 2016-07-29)

    One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the ...

    Design and synthesis of selective MMP-9 inhibitors for the treatment of epilepsy 

    Bertran Junqué, Alexandra (Date of defense: 2018-10-25)

    Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...

    Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays 

    Sanllehí Figuerola, Pol (Date of defense: 2016-11-02)

    Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...

    Design de candeeiros de iluminação pública para a a sustenibilidade do espaço público 

    Águas, Sofía (Date of defense: 2009-01-01)

    O:<br/><br/>O presente trabalho investiga os processos de design apropriados à eco-concepção de candeeiros de iluminação pública que possam contribuir para a sustentabilidade do espaço público urbano em geral. <br/>A ...

    Design of bioinformatic tools for integrative analysis of microRNA-mRNA interactome applied to digestive cancers 

    Vila Casadesús, Maria (Date of defense: 2017-09-05)

    En esta tesis se han desarrollado e implementado distintas herramientas bioinformáticas que permiten el estudio de las interacciones miRNA-mRNA en contextos celulares específicos. oncretamente se ha creado un paquete de R ...

    Design of Catalytic Systems based on Halogen Bonding Interactions: Synthesis and Application in Catalytic Reactions 

    Martínez Bascuñana, Alba (Date of defense: 2023-09-01)

    [eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...

    Design of Homogenous Territorial Units. A Methodological Proposal and Applications 

    Duque Cardona, Juan Carlos (Date of defense: 2004-09-30)

    The interest in geographical information technologies has grown considerably over the last three decades. Today, geographical information is no longer the exclusive domain of government and public administrations (in the ...

    Design of multifunctional polymeric nanoparticles for biomedical applications 

    Leitner, Stefanie (Date of defense: 2013-12-20)

    The general objective of this research was the design of polymeric cationic nanoparticles from nano-emulsions obtained by low-energy methods for biomedical applications. This general objective includes the preparation of ...

    Design of novel compositionally controlled hybrid and ternary nanostructures 

    Dalmases Solé, Mariona (Date of defense: 2019-02-08)

    The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...

    Design of peptides able to modulate Protein-protein interactions (PPIs) in mutated p53 

    Nicolini, Federica (Date of defense: 2022-12-02)

    [eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. On the contrary, ...

    Design, characterization and applications of polyester nanoparticles obtained by enzymatic polymerization in nano-emulsions prepared by low-energy methods 

    Paulme, Camille (Date of defense: 2013-02-01)

    The presence of volatile fragrant molecules is generally associated with a feeling of pleasantness or cleanness in consumer products. Because of their high volatilities, the perception of fragrances is limited over time. ...

    Design, characterization and optimization of a novel liposomal based food supplement against chronic fatigue syndrome 

    Ruiz García, Marta (Date of defense: 2020-10-20)

    In today’s society, people’s interest against health care is growing every day. On a health- concerned population, food supplements and nutraceuticals are products with an increasing interest among the global community. ...

    Design, synthesis and biological evaluation of new polymer-drug conjugates based on polyglutamic acid and 5-Fluorouracil for the treatment of advanced colorectal cancer 

    Plà Solans, Helena (Date of defense: 2014-11-13)

    Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment involves high doses of ...

    Design, synthesis and biological evaluation of photoswitchable molecules targeting G protein-coupled receptors in retina 

    González Díez, Aleix (Date of defense: 2023-07-24)

    [eng] G protein-coupled-receptors (GPCRs) are the largest family of membrane proteins and mediate important cellular responses. Metabotropic glutamate receptors (mGlu) belong to the Glutamate family/Class C GPCR. These ...

    Design, synthesis and biophysical evaluation of peptides targeting pharmacologically relevant proteins 

    Guardiola Bagán, Salvador (Date of defense: 2017-09-15)

    Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed to provide effective ...