Browsing by Title

Epidemiology of pestivirus infection in pyrenean Chamois (rupicapra pyrenaica pyrenaica) and other wild and domestic ruminants

Fernández Sirera, Laura (Date of defense: 2012-07-13)

Des de l’any 2001, diferents brots d’una malaltia associada a la infecció per un pestivirus, concretament un virus de la malaltia de la frontera de genotip 4 (BDV-4, de l’anglès border disease virus), han causat reduccions ...

Epidemiology of taeniosis and cysticercosis in Europe

Laranjo González, Minerva (Date of defense: 2018-09-26)

Taenia solium i Taenia saginata són dos paràsits zoonòtics que causen teniasi en persones (hoste definitiu) i cisticercosi en porcí i boví (hoste intermediari), respectivament. A Europa, T. saginata ha estat present durant ...

Epidemiology, population structure, and pathogenesis of opportunistic respiratory tract colonising bacteria

Carreras Salinas, Anna (Date of defense: 2022-12-21)

[eng] The bacterial colonisation of the respiratory tract is critical for health as it establishes a symbiotic relationship between the bacterial community and the host. Haemophilus influenzae and Staphylococcus aureus are ...

Epidemiology, vaccination and infection in wild ruminants with bluetongue virus

Lorca Oró, Cristina (Date of defense: 2012-11-09)

La llengua blava (LB) és una malaltia transmesa per vectors Culicoides de declaració obligatòria causada pel virus de la llengua blava (VLB) i considerada emergent i re-emergent a Europa. Aquesta malaltia afecta principalment ...

Epigallocatechin-3-gallate combined with cognitive training in young adults with Down syndrome Phase II clinical trial: Important considerations for treatment- efficacy evaluation on cognitive and functional improvement

del Hoyo Soriano, Laura (Date of defense: 2016-07-25)

Introducción: El síndrome de Down es un trastorno del neurodesarrollo causado por la trisomía 21 que conduce a una serie de déficits cognitivos y funcionales, un alto riesgo de desarrollo precoz de la enfermedad de Alzheimer ...

Epigenetic alterations in autism spectrum disorders (ASD)

Homs Raubert, Aïda (Date of defense: 2015-09-15)

The aetiology of autism spectrum disorders (ASD), a group of neurodevelopmental conditions with early onset, characterized by social and communication impairment and restricted interests, is unknown in about a third of the ...

An epigenetic approach to fatty acid metabolism in haematological malignancies

Maher, Michael (Date of defense: 2021-05-07)

The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic ...

Epigenetic deregulation of WT1 and AWT1 in hematological maligancies

Guillaumet Adkins, Amy Lauren (Date of defense: 2012-12-13)

En l’última dècada, s’ha posat en evidència que el càncer és tant una malaltia genètica com epigenètica. La desregulació epigenètica pot afectar molts processos cel·lulars, com són el silenciament de gens supressors de ...

Epigenetic Dysregulation of Monocytes as a Sensor of Activity and Progression in Arthritis

Calle Fabregat, Carlos de la (Date of defense: 2022-03-15)

OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with ...

Epigenetic information contained in male germ cell chromatin-associated proteins and its potential impact on the reproductive function

Iglesia Rodríguez, Alberto de la (Date of defense: 2022-10-28)

[eng] Contrasting the traditional idea of the male gamete being a simple carrier of the paternal DNA, evidence in the last decades revealed that the sperm cell provides the embryo with different layers of epigenetic ...

Epigenetic inheritance and DNA replication in Caenorhabditis elegans

Reis, Kadri (Date of defense: 2016-03-23)

Una gran proporción del genoma de la mayoría de eucariotas superiores está formado por secuencias repetitivas de DNA que contienen señales de represión de la transcripción. Para entender mejor cómo funciona la herencia ...

Epigenetic mechanisms in colorectal cancer

Custodio Rojo, Joaquín (Date of defense: 2014-10-15)

Mitjançant tècniques d’anàlisi de tot el genoma hem sigut capaços d'identificar regions diferencialment metilades entre teixit de colon normal i tumoral provinents del mateix pacient. Un dels gens més importants és AKR1B1, ...

Epigenetic Mechanisms in Monocyte-Associated Differentation and Inflammation Processes

Vento Tormo, Roser (Date of defense: 2016-01-22)

En aquesta tesi s’han estudiat els mecanismes epigenètics implicats en diferents processos d’inflamació i diferenciació a partir de monòcits (MO). És possible recapitular la diferenciació terminal de MO a cèl·lules ...

Epigenetic Mechanisms in two primary immunodeficiencies: Hyper-IgM Syndrome and Common Variable Immunodeficiency

Rodríguez Cortez, Virginia Carolina (Date of defense: 2015-02-06)

The proper function of the immune system requires complex regulatory mechanisms and a highly strict balance in the amount and function of immune and non-immune elements. Part of the primary immunodeficiencies result from ...

Epigenetic regulation mediated by antisense non-coding RNAs and its impact on oncogenic pathways: the HMGA2/RPSAP52 locus

Oliveira Mateos, Cristina (Date of defense: 2020-06-16)

The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory roles in the transcription ...