Browsing by Title

Functional Role of Glycogen synthase Kinase-3β on Glucocorticoid-mediated signaling

Rubio Patiño, Camila (Date of defense: 2012-10-31)

Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...

Functional role of pentose phosphate pathway and glutamine in cancer cell metabolism

Polat, Ibrahim H. (Date of defense: 2016-11-04)

In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...

Functional studies of 4F2hc-CD147 interaction = Estudios funcionales de la interacción 4F2hc‐CD147

Delgado Martin, Gonzalo (Date of defense: 2014-07-14)

We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...

Functional studies on the circadian regulation of mitochondrial activity in Arabidopsis thaliana

Cervela Cardona, Luis Manuel (Date of defense: 2019-11-21)

El reloj circadiano es un mecanismo celular endógeno capaz de medir el paso del tiempo y traducir las señales medioambientales, principalmente luz y temperatura, en respuestas temporales que resultan en ritmos metabólicos ...

Functional study of the NIMA protein kinases Nek9, Nek6 and Nek7 at the onset of mitosis. Control of the kinesin Eg5 and prophase centrosome separation

Eibes González, Susana (Date of defense: 2016-09-13)

Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this process: cyclin- ...

Functional surfaces by means of nanoimprint lithography techniques

Fernández Estévez, Ariadna (Date of defense: 2016-11-25)

Diferentes funcionalidades pueden ser obtenidas en diversas superficies a través de topografía en lugar de química, inspirándose en la naturaleza. El principal objetivo de esta tesis es la investigación de la litografía ...

Functional surfaces obtained by thermal spray techniques

Robotti, Marco (Date of defense: 2016-09-29)

The main subject of this PhD Thesis is the manufacturing of titanium dioxide multifunctional coatings by means of two spraying technologies: Cold Gas Spray (CGS) and Atmospheric Plasma Spray (APS). The characteristics of ...

Functional, genomic and molecular characterisation of Mtl1, an element of the CWI pathway of Saccharomyces cerevisiae with a role in the oxidative stress response

Ivanova Petkova, Mima (Date of defense: 2011-09-16)

Saccharomyces cerevisiae és un microorganisme eucariota que s’utilitza com a model per l’estudi de les vies de transducció de senyal implicades en la resposta a estrès oxidatiu. Fins l’actualitat, no s’ha descrit ...

Functionalisation of sp3 C-O bonds and olefins enabled by nickel catalysis

Talavera Codina, Laura (Date of defense: 2023-09-21)

En els darrers anys, la catàlisi de níquel ha guanyat un impuls considerable com a vehicle per permetre reaccions de formació d'enllaços amb una eficiència excepcional. Això es deu probablement a la facilitat amb què els ...

Functionalization of a Ti-based alloy with synthesized recombinant fibronectin fragments to improve cellular response

Herranz Díez, Carolina (Date of defense: 2014-07-22)

According to a study of the European Commission, approximately one million hips are replaced by prostheses worldwide every year. The interaction of the human body with foreign materials that are subjected to alternating ...

Functionalization of carbon nanomaterials with nitrogen, halides and oxides

Sandoval Rojano, Stefania (Date of defense: 2016-07-28)

Los materiales compuestos por grafeno y nanotubos de carbono (CNTs) han despertado un amplio interés debido a sus propiedades excepcionales. La variación de éstas, empleando diversas técnicas de modificación aumentan sus ...

Functionalization of carbon nanostructures by inorganic nanocrystals and potential applications

Oliveras i Solà, Jana (Date of defense: 2022-05-30)

Per desenvolupar l’aplicabilitat dels materials híbrids CNS-NP és de vital importància i) produir components d’alta qualitat que permetin una metodologia d’acoblament robusta, reproduïble i versàtil i ii) que el mètode ...

Functionalization of strong sigma bonds by Nickel and Tungsten catalysis

Martín Montero, Raúl (Date of defense: 2021-01-15)

Durant els últims anys, la funcionalització d’enllaços sigma forts mitjançant catàlisis amb metalls de transició ha rebut una atenció exponencial en el camp de la química orgànica. Especialment, la ruptura d’enllaços C–O, ...

Functionalization of titanium surfaces with TGF-beta inhibitor peptides

Sevilla Sánchez, Pablo (Date of defense: 2013-07-16)

Esta tesis queda enmarcada en el ámbito de los biomateriales metálicos, concretamente en superficies de titanio desarrolladas para la regeneración ósea. Las aplicaciones más habituales del titanio como biomaterial son los ...

Functionalization of titanium with integrin-selective ligands for orthopedic and dental applications

Fraioli, Roberta (Date of defense: 2016-11-14)

Despite being biocompatible and with adequate mechanical properties for application as a bone replacement material, titanium lacks osteoinductive capacity, i.e. it supports new bone growth on its surface but does not foster ...

Functionalized adsorbent materials using supercritical CO2

López-Aranguren Oliver, Pedro (Date of defense: 2014-11-18)

La silica (SiO2) porosa es uno de los adsorbentes históricamente más utilizado a nivel industrial en multitud de procesos. Sin embargo, el crecimiento acelerado de la demanda de nuevos materiales basados en nanotecnología ...

Functionalized carbon nanotubes for detecting traces of benzene vapours employing screen-printed resistive and resonant transducers

Clément, Pierrick (Date of defense: 2015-09-24)

Capes de nanotubs de carboni de múltiples parets (MWCNTs) s'han dipositat sobre diferents substrats transductors per a aplicacions de detecció de gasos. MWCNTs tractats amb plasma d'oxigen, anomenats O-MWCNTs, han estat ...